{"id":"W2949203676","doi":"10.1074/mcp.ra118.001093","title":"Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways*","year":2019,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Government of Canada; University of Saskatchewan; Canadian Light Source","keywords":"Effector; Salmonella; Signal transduction; Cell biology; Signaling proteins; Tumor necrosis factor alpha; Death domain; Computational biology; Biology; Chemistry; Programmed cell death; Biochemistry; Genetics; Apoptosis; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001259306,0.0002867875,0.0003727897,0.00002474557,0.0001297646,0.00009398771,0.0003058864,0.0002335602,0.00003972478],"category_scores_gemma":[0.00005890209,0.0001171313,0.0001019013,0.000222186,0.00008883983,0.00006786703,0.0001099489,0.0003177363,0.00001758969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002308554,"about_ca_system_score_gemma":0.00001199511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001828042,"about_ca_topic_score_gemma":0.00002563251,"domain_scores_codex":[0.9977474,0.0006740954,0.0003252945,0.0005700514,0.0001992567,0.0004839438],"domain_scores_gemma":[0.9993717,0.0002301717,0.0001200586,0.0001482429,0.00002390984,0.0001058883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003755819,0.00004841028,0.03443518,0.00002801486,0.00001314263,0.0000679139,0.0003030612,0.00001960792,0.9626961,0.0009209185,0.000004482721,0.001425601],"study_design_scores_gemma":[0.000925051,0.0009655534,0.1002698,0.00008989264,0.00003287489,0.0001137675,0.0009249353,0.0005314818,0.8736626,0.01945567,0.002250603,0.0007777587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958724,0.001176387,0.0002454301,0.000569912,0.00005696399,0.001794097,0.00001274613,0.00003516812,0.0002368809],"genre_scores_gemma":[0.9975613,0.00004203678,0.001610264,0.0005192474,0.00007559804,0.0001178145,0.0000461336,0.000005073181,0.00002252353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08903351,"threshold_uncertainty_score":0.4776478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195199040065004,"score_gpt":0.1921433886128526,"score_spread":0.1801913982122025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}