{"id":"W2949203676","doi":"10.1074/mcp.ra118.001093","title":"Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways*","year":2019,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Government of Canada; University of Saskatchewan; Canadian Light Source","keywords":"Effector; Salmonella; Signal transduction; Cell biology; Signaling proteins; Tumor necrosis factor alpha; Death domain; Computational biology; Biology; Chemistry; Programmed cell death; Biochemistry; Genetics; Apoptosis; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829347,0.0004948824,0.0002252163,0.0001366792,0.0001103806,0.0003948633,0.0001459973,0.0003827098,0.0007754705],"category_scores_gemma":[0.0001067903,0.0001061877,0.0003661961,0.0001076391,0.0002399764,0.0001745653,0.0003379831,0.0005438998,0.0005308795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003851389,"about_ca_system_score_gemma":0.0001791856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002248445,"about_ca_topic_score_gemma":0.0003262954,"domain_scores_codex":[0.9998332,0.00002333058,0.00002207109,0.00002400968,0.00005261384,0.00004474392],"domain_scores_gemma":[0.9998516,0.00001401043,0.00006096298,0.00001923227,0.00001847466,0.00003576034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008880501,0.00001565591,0.0004955341,0.00001641085,0.000003297522,0.00003416573,0.000005149842,0.00004062569,0.9985076,0.00007716801,0.00001724102,0.0006983301],"study_design_scores_gemma":[0.00001032445,0.0002318047,0.006578025,0.000004228804,0.00001148978,0.0005526631,0.00003665469,0.0006464713,0.9900904,0.00004152344,0.001791686,0.000004816641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993733,0.0008013498,0.004192502,0.00009754783,0.00002715305,0.00002791295,0.0002577266,0.0000749742,0.0007877813],"genre_scores_gemma":[0.9925391,0.0003126469,0.004186413,0.00006786651,0.000005280207,0.00002360004,0.0006827188,0.00001840404,0.002163952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007754705,"threshold_uncertainty_score":0.002794385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195199040065004,"score_gpt":0.1921433886128526,"score_spread":0.1801913982122025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}