{"id":"W2949211784","doi":"10.1246/cl.2004.1212","title":"The First Enantiomerically Pure Synthesis of (<i>S</i>)- and (<i>R</i>)-Naftopidil Utilizing Hydrolytic Kinetic Resolution of (±)-(α-Naphthyl) Glycidyl Ether","year":2004,"lang":"en","type":"article","venue":"Chemistry Letters","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Kinetic resolution; Ether; Hydrolysis; Organic chemistry; Stereochemistry; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060897,0.0006460967,0.0002736512,0.0002024838,0.0001884757,0.0004829367,0.0004393145,0.0004442685,0.001199717],"category_scores_gemma":[0.0002659702,0.0002763185,0.0002699572,0.0001756556,0.0002405321,0.000405889,0.0002236577,0.0005383283,0.00100935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145118,"about_ca_system_score_gemma":0.0004039746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005906034,"about_ca_topic_score_gemma":0.001160701,"domain_scores_codex":[0.9998307,0.00002207642,0.00001790236,0.00003993523,0.00004443081,0.00004485681],"domain_scores_gemma":[0.9998691,0.00001858564,0.00003406226,0.00002111632,0.00002941028,0.00002763723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003918797,0.00001074414,0.00003930722,0.00003857001,0.000005355832,0.00007616344,0.00002574244,0.00006561379,0.9968929,0.0003127258,0.00007884446,0.002414706],"study_design_scores_gemma":[0.000005775548,0.00003925234,0.00007737361,0.00000129892,0.000005135718,0.00006302794,0.000007542101,0.00009993638,0.9979154,0.00002020986,0.001761237,0.000003781611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9285834,0.002376419,0.04519804,0.0003365303,0.000183252,0.0003196393,0.002002361,0.0005187677,0.02048156],"genre_scores_gemma":[0.9436899,0.002172056,0.04175778,0.0001580595,0.00003429484,0.0001616107,0.001508778,0.0002467936,0.01027067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199717,"threshold_uncertainty_score":0.004013479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600715437130341,"score_gpt":0.2050100919840439,"score_spread":0.1994093765469136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}