{"id":"W2949216246","doi":"10.1016/j.bmcl.2005.11.009","title":"Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Pyrimidinones; Chemistry; Staphylococcus aureus; Polymerase; DNA polymerase; Nucleobase; DNA; Bacteria; Antibacterial agent; DNA replication; Antibacterial activity; In vitro; Biochemistry; Microbiology; Stereochemistry; Antibiotics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002414974,0.0007289182,0.0007057872,0.0004330295,0.0002853598,0.0004818088,0.0006938815,0.000430563,0.002558224],"category_scores_gemma":[0.000282957,0.0003135734,0.0003179226,0.0002002566,0.0001892589,0.0002077095,0.0003368142,0.000868172,0.0008599435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000459439,"about_ca_system_score_gemma":0.0002957926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008999711,"about_ca_topic_score_gemma":0.002542038,"domain_scores_codex":[0.9998509,0.00002330366,0.00001081776,0.00002684935,0.00003818814,0.00004997278],"domain_scores_gemma":[0.9999013,0.00002527326,0.00001858096,0.000007552772,0.00001597194,0.0000312715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001177586,0.0004541698,0.0004187102,0.0004324077,0.00009637077,0.0006141203,0.0001104184,0.001861811,0.9368179,0.001580993,0.001570344,0.05486514],"study_design_scores_gemma":[0.0008475663,0.004066916,0.001918972,0.00007557907,0.0001216873,0.001542846,0.00004060686,0.004714417,0.95162,0.0003902147,0.03461632,0.00004473417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8941283,0.0511344,0.02190821,0.000763785,0.0009958139,0.0007009968,0.0009917236,0.0008775807,0.02849911],"genre_scores_gemma":[0.9622983,0.01555428,0.007644068,0.0004861011,0.0001487432,0.0002064059,0.001038849,0.00007398573,0.01254936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002558224,"threshold_uncertainty_score":0.008558154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011577620399788,"score_gpt":0.2480739784020463,"score_spread":0.2379582021980484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}