{"id":"W2949216637","doi":"10.1139/v05-054","title":"Synthesis of fused pyrazolo-, isoxazolo-, pyrimido-, and pyridopyrimidines","year":2005,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Isoxazole; Condensation; D-1; Stereochemistry; Medicinal chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001560169,0.0002095456,0.0004412802,0.00009975201,0.00009246563,0.00005644902,0.0003742489,0.0001800601,0.003275814],"category_scores_gemma":[0.0003205911,0.000204881,0.0001640763,0.00008157636,0.0002144533,0.0001619363,0.00002143151,0.0002182999,0.000003974251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114454,"about_ca_system_score_gemma":0.0004560252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001418024,"about_ca_topic_score_gemma":0.0001781749,"domain_scores_codex":[0.9986309,0.000009097571,0.0006805136,0.0001752315,0.000204545,0.0002997334],"domain_scores_gemma":[0.9982527,0.0001647678,0.0005280486,0.000274492,0.0001962151,0.0005837556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003342318,0.00003538533,0.005176063,0.0002116328,0.0001012546,0.00002984249,0.0002350416,0.00001426313,0.973148,0.00001132741,0.001012865,0.01999092],"study_design_scores_gemma":[0.0003270607,0.000008063479,0.001080702,0.0002140098,0.00005682368,0.0002768567,0.0003254539,0.00006065241,0.9521332,0.00003909616,0.04527374,0.0002043671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863315,0.001064918,0.000009089001,0.00120227,0.00006792351,0.00001616626,0.00004413654,0.00001088587,0.01125309],"genre_scores_gemma":[0.9985316,0.000143659,0.0001721735,0.00008335878,0.0005601113,0.000002631791,0.000004352297,0.00003008887,0.0004719738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04426088,"threshold_uncertainty_score":0.9976353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009348983518920065,"score_gpt":0.1992003401793329,"score_spread":0.1898513566604129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}