{"id":"W2949230885","doi":"10.1016/j.devcel.2019.05.037","title":"Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Marine Biological Laboratory; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; Ministerio de Ciencia, Innovación y Universidades; Surdna Foundation; National Institutes of Health; March of Dimes Foundation","keywords":"Biology; Maternal to zygotic transition; Enhancer; Histone; Genetics; Genome; Zebrafish; Reprogramming; Transcription (linguistics); BRD4; Zygote; Epigenetics; Gene; Acetylation; Regulation of gene expression; Transcription factor; Cell biology; Bromodomain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323795,0.0002996506,0.0003068378,0.0003638056,0.0002839261,0.0008066327,0.0006004296,0.0003986409,0.002773823],"category_scores_gemma":[0.0005427638,0.0003940214,0.0002808371,0.0001945603,0.000455246,0.0003915334,0.0007577925,0.001054817,0.001008254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008663656,"about_ca_system_score_gemma":0.0003413355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321351,"about_ca_topic_score_gemma":0.003999387,"domain_scores_codex":[0.9996012,0.00006422876,0.00002884809,0.00006463438,0.0001185582,0.0001225415],"domain_scores_gemma":[0.9995441,0.0001814904,0.00003866986,0.00007632005,0.00003734951,0.0001221043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235107,0.0000091937,0.0001189994,0.00001028837,0.000001630654,0.00005155367,0.00001062904,0.00003355544,0.9988348,0.0002707527,0.00002030041,0.0005147695],"study_design_scores_gemma":[0.000008252864,0.00002133094,0.002753971,0.000001882789,0.000003200546,0.00009999027,0.00002031038,0.0005965098,0.9957349,0.00005964261,0.0006968151,0.000003127745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801133,0.001838564,0.01009434,0.0001970571,0.00005738886,0.00003964474,0.0005533898,0.0002121717,0.006894181],"genre_scores_gemma":[0.9912406,0.0002063561,0.002265801,0.00004559355,0.00001084787,0.0000170737,0.0005462205,0.00006391255,0.005603639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002773823,"threshold_uncertainty_score":0.00927937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003448241075674817,"score_gpt":0.1644867414568003,"score_spread":0.1610385003811255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}