{"id":"W2949230885","doi":"10.1016/j.devcel.2019.05.037","title":"Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Marine Biological Laboratory; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; Ministerio de Ciencia, Innovación y Universidades; Surdna Foundation; National Institutes of Health; March of Dimes Foundation","keywords":"Biology; Maternal to zygotic transition; Enhancer; Histone; Genetics; Genome; Zebrafish; Reprogramming; Transcription (linguistics); BRD4; Zygote; Epigenetics; Gene; Acetylation; Regulation of gene expression; Transcription factor; Cell biology; Bromodomain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000393278,0.0001036447,0.00008013405,0.00002569652,0.00005817552,0.0000210693,0.0000711964,0.00006534278,0.0001182306],"category_scores_gemma":[0.000001441207,0.0001100983,0.00002593511,0.00002698287,0.00002173137,0.000004231279,0.00005098279,0.000046748,0.00004635492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002796819,"about_ca_system_score_gemma":0.00006628742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000383238,"about_ca_topic_score_gemma":0.000004762674,"domain_scores_codex":[0.999435,0.000009681531,0.0001317721,0.0002137022,0.00007245455,0.000137404],"domain_scores_gemma":[0.9998201,0.000002469191,0.00003649778,0.00007542029,0.00002136966,0.00004420529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001799189,0.00002470038,0.006721328,0.00004646165,0.00001429381,6.371497e-7,0.00009783015,0.00002991659,0.9928817,0.00009209463,0.000008131382,0.0000649628],"study_design_scores_gemma":[0.001366107,0.00008567068,0.5689833,0.00001389884,0.000007613442,0.00004141594,0.0002912013,0.000175377,0.4227941,0.00008710622,0.005784171,0.0003700464],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939685,0.00008627168,0.0001540069,0.00003325815,0.00006747871,0.0001405154,0.00001182063,0.000006248662,0.005531838],"genre_scores_gemma":[0.9952312,0.00005625613,0.00234529,0.0001119162,0.00002852476,0.000005467622,0.000289777,0.00001498216,0.00191656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5700876,"threshold_uncertainty_score":0.4489677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003448241075674817,"score_gpt":0.1644867414568003,"score_spread":0.1610385003811255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}