{"id":"W2949245260","doi":"10.1021/ol5002945","title":"DMAP Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Diastereomer; Tandem; Nucleophile; Nucleophilic addition; Cascade reaction; Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534128,0.000129605,0.0001363495,0.00001441726,0.0004486883,0.00003150593,0.0001589376,0.00006684475,0.000637704],"category_scores_gemma":[0.00009239386,0.00005303486,0.0000548073,0.0003356684,0.00007442735,0.0001769595,0.00004281589,0.0001859296,0.0001109947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005277216,"about_ca_system_score_gemma":0.000003085699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004725088,"about_ca_topic_score_gemma":0.0002098969,"domain_scores_codex":[0.9991463,0.00007984885,0.0001608014,0.0002294467,0.0001293721,0.000254247],"domain_scores_gemma":[0.9995431,0.000239582,0.00008155566,0.00004338147,0.0000365629,0.00005578856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004881001,0.00002207317,0.0007977871,0.000002684205,0.00002024972,0.000002472757,0.00002946611,8.095722e-7,0.9891126,0.00004924078,0.005154314,0.004803483],"study_design_scores_gemma":[0.0007388776,0.000215188,0.1672411,0.00006055067,0.0001196439,0.00009920906,0.0001824853,0.0002946003,0.5264229,0.000673585,0.3031038,0.0008481266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838172,0.00003417284,0.0000322759,0.01507709,0.000450569,0.0001534314,0.000009001212,0.0001977915,0.0002284487],"genre_scores_gemma":[0.997225,0.00001467542,0.0001004883,0.002020301,0.0004943564,0.00001295905,0.00007529157,0.000001392672,0.00005554799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4626897,"threshold_uncertainty_score":0.6982412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535174264796148,"score_gpt":0.221800257472488,"score_spread":0.2064485148245265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}