{"id":"W2949245789","doi":"10.1038/s41420-018-0104-z","title":"Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Athabasca University; University of Winnipeg; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Manitoba; Government of Canada; Children's Hospital Foundation; Research Manitoba; Athabasca University; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Biology; Psychological repression; Hypoxia (environmental); Programmed cell death; Endoplasmic reticulum; Unfolded protein response; NFAT; Alternative splicing; Gene expression; Transcription factor; Exon; Gene; Apoptosis; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107007,0.0002649728,0.000278849,0.00007540675,0.0002013176,0.0001037215,0.0001883394,0.0001403284,0.00001250103],"category_scores_gemma":[0.0000466365,0.0002420932,0.0001017512,0.00008133853,0.0001069502,0.00002448836,0.0002190956,0.0000930423,0.000009281719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002431918,"about_ca_system_score_gemma":0.00004647188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001740929,"about_ca_topic_score_gemma":0.00003198606,"domain_scores_codex":[0.9984198,0.00005625808,0.000241614,0.0006984012,0.000172181,0.0004117466],"domain_scores_gemma":[0.9990568,0.00001606768,0.0001144314,0.000530122,0.00008807884,0.0001945179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000330208,0.00005085715,0.001604772,0.00006083912,0.00004657734,0.000006151563,0.0002299836,0.0001081884,0.9954299,0.00002018692,0.0004418175,0.001670463],"study_design_scores_gemma":[0.001317544,0.00017291,0.008693225,0.0000831319,0.00006453793,0.00001010316,0.0001797415,0.00007615463,0.9832712,0.00004803026,0.005762083,0.0003213791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988484,0.006930014,0.002576289,0.00004933728,0.0008622665,0.0003841271,0.0001354664,0.00001800301,0.0005605092],"genre_scores_gemma":[0.9931854,0.0006969068,0.0002004418,0.0002508598,0.002396026,0.00003749258,0.00005092967,0.00004467184,0.003137284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121588,"threshold_uncertainty_score":0.9872272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009275539678825826,"score_gpt":0.239791335842613,"score_spread":0.2305157961637871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}