{"id":"W2949245789","doi":"10.1038/s41420-018-0104-z","title":"Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Athabasca University; University of Winnipeg; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Manitoba; Government of Canada; Children's Hospital Foundation; Research Manitoba; Athabasca University; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Biology; Psychological repression; Hypoxia (environmental); Programmed cell death; Endoplasmic reticulum; Unfolded protein response; NFAT; Alternative splicing; Gene expression; Transcription factor; Exon; Gene; Apoptosis; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083671,0.0002084877,0.0001718458,0.0001231248,0.0001355098,0.0002529477,0.0001328618,0.0001783747,0.0007647389],"category_scores_gemma":[0.00009697716,0.00008241491,0.000218423,0.0001066044,0.0002599789,0.0001690253,0.0001631077,0.0005226152,0.0001970414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641298,"about_ca_system_score_gemma":0.0002019901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000394126,"about_ca_topic_score_gemma":0.0006178796,"domain_scores_codex":[0.9999012,0.00001305725,0.000008892578,0.00002608557,0.00002238777,0.00002827374],"domain_scores_gemma":[0.999904,0.00001163011,0.00003812016,0.000007743665,0.00001208795,0.00002634565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002522313,0.00001317476,0.0001535067,0.00001785114,0.000001914299,0.00004222332,0.000009927451,0.00002437154,0.9987131,0.00008182193,0.00002382096,0.0006659359],"study_design_scores_gemma":[0.00003060955,0.0001969589,0.007845732,0.000006584759,0.00001684316,0.0001875431,0.00004334443,0.000820898,0.9887164,0.000120384,0.002009425,0.000005253604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927847,0.002133905,0.00333946,0.000191339,0.00007998944,0.00002619619,0.0002849538,0.00005274298,0.001106742],"genre_scores_gemma":[0.9943095,0.001247322,0.00197483,0.0001108279,0.00002450764,0.00004028122,0.0003996537,0.00002048811,0.00187238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007647389,"threshold_uncertainty_score":0.002558291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009275539678825826,"score_gpt":0.239791335842613,"score_spread":0.2305157961637871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}