{"id":"W2949252818","doi":"10.1021/jacs.9b02822","title":"Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministry of Science and Technology, Israel; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; Wellcome; Merck KGaA; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Rising Tide Foundation; Pfizer; Israel Science Foundation; Israel Cancer Research Fund","keywords":"Chemistry; Electrophile; Covalent bond; Ligand efficiency; Combinatorial chemistry; Drug discovery; Fragment (logic); Ligand (biochemistry); Cysteine; Selectivity; Deubiquitinating enzyme; Stereochemistry; High-throughput screening; Enzyme; Biochemistry; Organic chemistry; Receptor; Gene; Ubiquitin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008438640852305347,"score_gpt":0.2361901191006167,"score_spread":0.2277514782483114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}