{"id":"W2949277270","doi":"10.1016/s0065-3160(02)37004-7","title":"Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer","year":2002,"lang":"en","type":"book-chapter","venue":"Advances in physical organic chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Glycosyl; Kinetic isotope effect; Computational chemistry; Reactivity (psychology); Catalysis; Transition state; Hydrolysis; Enzyme catalysis; Glycoside; Organic chemistry; Combinatorial chemistry; Deuterium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759939,0.0004667253,0.0004860809,0.0004842112,0.0002384312,0.0006470106,0.001499375,0.0004275789,0.002171625],"category_scores_gemma":[0.0003863221,0.0003823387,0.0005456213,0.0005705411,0.0005201931,0.001215427,0.0003126942,0.001299103,0.0005427932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005683264,"about_ca_system_score_gemma":0.00025139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000397187,"about_ca_topic_score_gemma":0.0004513115,"domain_scores_codex":[0.9998925,0.00001308118,0.00000453245,0.0000372516,0.00004197182,0.0000107126],"domain_scores_gemma":[0.9998884,0.00006767053,0.000008564049,0.00001621431,0.00001450998,0.000004549114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003359478,0.0001396686,0.0004587643,0.0006345823,0.00007750822,0.000136183,0.0001679847,0.01325657,0.7114401,0.1050603,0.003550373,0.1647419],"study_design_scores_gemma":[0.00001535416,0.00007905796,0.001044113,0.000019356,0.00005295131,0.0002471686,0.00003710485,0.1837436,0.7672843,0.03752177,0.009894925,0.00006027464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1094185,0.01013083,0.8662471,0.0003042796,0.0002531311,0.00005913333,0.0003493796,0.002115599,0.01112205],"genre_scores_gemma":[0.7492321,0.01058626,0.2205489,0.0001761099,0.00007348197,0.0001472963,0.0007472116,0.0006018678,0.01788673],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002171625,"threshold_uncertainty_score":0.007264853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003718283995229488,"score_gpt":0.1986957786863043,"score_spread":0.1949774946910748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}