{"id":"W2949328920","doi":"10.1002/ana.25308","title":"Variation at the <i>TRIM11</i> locus modifies progressive supranuclear palsy phenotype","year":2018,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; PSP Association; Parkinson's UK; Innovate UK; Alzheimer's Society; Medical Research Council Canada; University College London","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Progressive supranuclear palsy; Genetic association; Biology; Genetics; Locus (genetics); SNP; Minor allele frequency; Cohort; Odds ratio; Phenotype; Bioinformatics; Genotype; Gene; Internal medicine; Medicine; Atrophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005564762,0.0005900118,0.0003643517,0.0005183699,0.0002811621,0.0003719032,0.0003908857,0.0005440208,0.003972113],"category_scores_gemma":[0.00116319,0.0001721172,0.0004749204,0.0005429995,0.0003330873,0.0001461202,0.0003632845,0.0003768229,0.0005833752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110064,"about_ca_system_score_gemma":0.0001679925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001512212,"about_ca_topic_score_gemma":0.001552248,"domain_scores_codex":[0.9994765,0.0001218634,0.00006457684,0.0002419754,0.0000578968,0.00003726388],"domain_scores_gemma":[0.9993242,0.0002075333,0.0002778111,0.0000934905,0.00003550727,0.00006145582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003177253,0.0002473911,0.6019253,0.0002300332,0.00148511,0.003558359,0.0002745044,0.001738045,0.3673801,0.0004121587,0.001242782,0.01832893],"study_design_scores_gemma":[0.00007356601,0.0003686047,0.9794086,0.00003567214,0.0004539546,0.003531138,0.0000482767,0.001876874,0.01314956,0.0002833658,0.0007524285,0.00001791727],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970246,0.0002078958,0.001146938,0.0000841115,0.0000125415,0.00001716415,0.0008966923,0.00007492898,0.0005350745],"genre_scores_gemma":[0.9982865,0.00006873309,0.0007373137,0.00008355421,0.00001250239,0.00001070271,0.0005125763,0.00002573502,0.0002623391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003972113,"threshold_uncertainty_score":0.01328802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386974938473319,"score_gpt":0.274003349722734,"score_spread":0.2501336003380008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}