{"id":"W2949365580","doi":"10.1007/s00277-019-03747-2","title":"Direct comparison of two extended-half-life recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A","year":2019,"lang":"en","type":"article","venue":"Annals of Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University","funders":"Chugai Pharmaceutical; LEO Pharma; Grifols; Daiichi Sankyo Europe; Sanofi; Bayer HealthCare; Swedish Orphan Biovitrum; Baxalta; CSL Behring; Biogen; Novo Nordisk; Alnylam Pharmaceuticals; Pfizer","keywords":"Medicine; Crossover study; Confidence interval; Pharmacokinetics; Adverse effect; Randomized controlled trial; Population; Half-life; Internal medicine; Gastroenterology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002879543,0.001869231,0.005099139,0.0005350135,0.0004709221,0.001369616,0.0008664568,0.001806229,0.003487928],"category_scores_gemma":[0.003178618,0.001179995,0.002349073,0.0005592563,0.001730632,0.001605258,0.0005081086,0.003302997,0.0008118934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009232378,"about_ca_system_score_gemma":0.001347223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006653693,"about_ca_topic_score_gemma":0.000980442,"domain_scores_codex":[0.9981382,0.0009741968,0.0001363453,0.0003978445,0.0001331501,0.0002202175],"domain_scores_gemma":[0.9970229,0.0008776691,0.0006584911,0.0003767802,0.0002056152,0.0008585751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9778314,0.01174894,0.0006995956,0.0001219594,0.0005946472,0.0000304154,0.00005453516,0.0001926161,0.003306093,0.00004624042,0.0001476553,0.005226023],"study_design_scores_gemma":[0.7072524,0.2883896,0.002493329,0.00000814508,0.0004615041,0.00003806124,0.00002507866,0.0004081202,0.0005014357,0.00008245261,0.0003188933,0.00002093197],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959794,0.00108926,0.0006048399,0.000136013,0.0002365664,0.001294163,0.000256857,0.00004697145,0.0003558965],"genre_scores_gemma":[0.9944187,0.0008565657,0.001115549,0.0003374183,0.0003737046,0.001652383,0.000404078,0.0000187623,0.0008229774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005099139,"threshold_uncertainty_score":0.01522869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04433606071016476,"score_gpt":0.382986038400816,"score_spread":0.3386499776906512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}