{"id":"W2949384592","doi":"10.1002/chin.200028216","title":"ChemInform Abstract: Design and Synthesis of Mimics of S‐Adenosyl‐L‐homocysteine as Potential Inhibitors of Erythromycin Methyltransferases.","year":2000,"lang":"en","type":"article","venue":"ChemInform","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Methyltransferase; Erythromycin; Combinatorial chemistry; Stereochemistry; Antibiotics; Methylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511367,0.0007806966,0.0004964307,0.0002909137,0.0002222624,0.000387432,0.0006583752,0.0006847183,0.005515542],"category_scores_gemma":[0.0002856846,0.0003677613,0.0003575936,0.000263502,0.0001829401,0.000456172,0.0003214467,0.0006314559,0.002265536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000518869,"about_ca_system_score_gemma":0.0006036907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005844941,"about_ca_topic_score_gemma":0.001013728,"domain_scores_codex":[0.9998643,0.00002953539,0.000012214,0.00002666654,0.00003314624,0.00003419516],"domain_scores_gemma":[0.9999262,0.000008396513,0.00001741427,0.000006447046,0.00001214205,0.0000293733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001574,0.0004315902,0.0001933202,0.001153322,0.0001073538,0.000701906,0.0001450791,0.005349598,0.9147028,0.004972607,0.007385329,0.06328302],"study_design_scores_gemma":[0.0004654714,0.002736951,0.0004199825,0.00005077741,0.00009295224,0.000557396,0.00002525115,0.004251824,0.9436437,0.0004439797,0.04725542,0.00005626849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7014101,0.04116657,0.14817,0.00191585,0.001715281,0.003083675,0.006730743,0.003749747,0.09205811],"genre_scores_gemma":[0.9095488,0.01690304,0.03924907,0.0004773099,0.00012882,0.0005393815,0.003943015,0.0001872468,0.02902344],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005515542,"threshold_uncertainty_score":0.01845133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004062471222824,"score_gpt":0.2324937763183666,"score_spread":0.2224531516061383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}