{"id":"W2949413659","doi":"10.1002/path.5314","title":"Oncogenic mutations in histologically normal endometrium: the new normal?","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"B.C. Women's Hospital & Health Centre; University of Calgary; Women's Health Research Institute; University of British Columbia; Vancouver General Hospital; Canadian Centre for Applied Research in Cancer Control; Calgary Laboratory Services; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; VGH and UBC Hospital Foundation","keywords":"PTEN; Endometrium; Somatic cell; Endometrial cancer; Endometriosis; Adenomyosis; Pathology; KRAS; Immunohistochemistry; Cancer research; Germline mutation; Medicine; Uterus; Malignant transformation; Biology; ARID1A; Mutation; Cancer; Internal medicine; Gene; Genetics; PI3K/AKT/mTOR pathway; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001403744,0.0000905655,0.0003217209,0.0004097598,0.00004992993,0.000006774683,0.0002514391,0.0000625439,0.0007471934],"category_scores_gemma":[0.001849903,0.00003885207,0.0001471745,0.0006098743,0.0001138333,0.00006003793,0.00005534616,0.000565784,0.0002832744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362295,"about_ca_system_score_gemma":0.0003026653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003406229,"about_ca_topic_score_gemma":0.00002411846,"domain_scores_codex":[0.9985356,0.0003824793,0.0004082347,0.00007310581,0.0003249192,0.0002757028],"domain_scores_gemma":[0.9970559,0.002240909,0.0002140535,0.0002331659,0.0001306795,0.0001252217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0130075,0.003826383,0.517073,0.0001230559,0.001559953,0.02306454,0.008065555,0.001343141,0.2753119,0.001876536,0.03204381,0.1227046],"study_design_scores_gemma":[0.02577414,0.0148651,0.8447242,0.00009873133,0.0005986977,0.05849056,0.001510664,0.00007153056,0.009385546,0.001612733,0.04263314,0.0002349088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813598,0.003393806,0.0002071287,0.009623911,0.0001840394,0.0003301951,0.000001861476,0.000004711666,0.00489454],"genre_scores_gemma":[0.9956039,0.001043993,0.0005377404,0.0005795007,0.0001199107,0.000003449789,0.000001770198,0.000007286514,0.00210251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3276513,"threshold_uncertainty_score":0.8181244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02560545442089877,"score_gpt":0.316621012606899,"score_spread":0.2910155581860002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}