{"id":"W2949413659","doi":"10.1002/path.5314","title":"Oncogenic mutations in histologically normal endometrium: the new normal?","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"B.C. Women's Hospital & Health Centre; University of Calgary; Women's Health Research Institute; University of British Columbia; Vancouver General Hospital; Canadian Centre for Applied Research in Cancer Control; Calgary Laboratory Services; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; VGH and UBC Hospital Foundation","keywords":"PTEN; Endometrium; Somatic cell; Endometrial cancer; Endometriosis; Adenomyosis; Pathology; KRAS; Immunohistochemistry; Cancer research; Germline mutation; Medicine; Uterus; Malignant transformation; Biology; ARID1A; Mutation; Cancer; Internal medicine; Gene; Genetics; PI3K/AKT/mTOR pathway; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00330379,0.0004548058,0.0007818308,0.002041991,0.0004493311,0.001754569,0.0007839529,0.0005998164,0.0009892738],"category_scores_gemma":[0.006983685,0.0003426364,0.0003270922,0.0008481406,0.00251475,0.001538003,0.00109316,0.0007056587,0.0002761487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004003416,"about_ca_system_score_gemma":0.0003658559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006646673,"about_ca_topic_score_gemma":0.001538816,"domain_scores_codex":[0.9979588,0.0005291863,0.0003312214,0.0003083059,0.0006863655,0.0001862378],"domain_scores_gemma":[0.9965327,0.0008166864,0.0008319574,0.0008536155,0.0006351189,0.0003299746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001020431,0.0001050593,0.76253,0.0006253006,0.0002149573,0.0130851,0.0009713739,0.0003184941,0.04718398,0.003459627,0.001667574,0.1688182],"study_design_scores_gemma":[0.00008720261,0.001592465,0.7303402,0.0008120367,0.0004317847,0.1808506,0.005948037,0.003109117,0.01784472,0.01639315,0.04247592,0.0001145933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383005,0.0434514,0.008834318,0.004902692,0.0004818728,0.00003800944,0.0002955497,0.00008696633,0.003608708],"genre_scores_gemma":[0.9865507,0.008247534,0.003480035,0.0006800904,0.000348746,0.00001502927,0.00015728,0.00002453153,0.000496076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00330379,"threshold_uncertainty_score":0.01747233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02560545442089877,"score_gpt":0.316621012606899,"score_spread":0.2910155581860002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}