{"id":"W2949417336","doi":"10.1002/chin.200739145","title":"Synthesis of Alkyl 6‐Methyl‐4‐ (2‐trifluoromethylphenyl) ‐1,2,3,4‐tetrahydro‐2H‐pyrimidine‐2‐one‐5‐carboxylates Possessing a N‐3 Nitro Substituent to Determine Calcium Channel Modulation Structure—Activity Relationships.","year":2007,"lang":"en","type":"article","venue":"ChemInform","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Substituent; Alkyl; Pyrimidine; Nitro; Stereochemistry; Modulation (music); Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008319828,0.0006383288,0.0008793126,0.0005329579,0.0003092448,0.00008836012,0.0006142211,0.0005515668,0.0004196722],"category_scores_gemma":[0.001848705,0.0006691371,0.0003150675,0.0003862144,0.0001734879,0.0006513279,0.0002029976,0.0005776586,0.00002308422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005349256,"about_ca_system_score_gemma":0.00006895943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002701312,"about_ca_topic_score_gemma":0.00007737531,"domain_scores_codex":[0.996255,0.000008076322,0.00121794,0.0007008447,0.0009050053,0.0009130642],"domain_scores_gemma":[0.9956048,0.001965167,0.0007189494,0.001021446,0.0002201805,0.0004695327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002872805,0.0001897652,0.002391628,0.0004871278,0.0001324548,0.000007140018,0.0004862869,0.0001561898,0.9093876,0.00001644549,0.00001731169,0.08644073],"study_design_scores_gemma":[0.0004673463,0.00001267183,0.02270821,0.0003624729,0.000156706,0.00001839329,0.0002135835,0.002505008,0.9726146,0.0001844997,0.0000842239,0.0006723162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885076,0.0001451779,0.0006179326,0.0001222162,0.0001735388,0.0003284203,0.0001150787,0.0002300163,0.009760032],"genre_scores_gemma":[0.9955246,0.00001089464,0.003812944,0.00002002627,0.0002887648,0.00004433399,0.00007074539,0.0001001613,0.0001275416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08576841,"threshold_uncertainty_score":0.999576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0497446249498339,"score_gpt":0.2767526781231989,"score_spread":0.227008053173365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}