{"id":"W2949447363","doi":"10.1002/art.41012","title":"The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Regeneron Pharmaceuticals","keywords":"Tolerability; Osteoarthritis; Placebo; Double blind; Medicine; Joint pain; Clinical trial; Physical therapy; Internal medicine; Adverse effect; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009443587,0.0004823809,0.004854646,0.0002521609,0.0001987574,0.0000557425,0.0001760141,0.0004871126,0.0002734503],"category_scores_gemma":[0.00264322,0.0003529219,0.0008741881,0.0002414388,0.001066932,0.0001446185,0.000169585,0.0006066549,0.00006989996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005511278,"about_ca_system_score_gemma":0.0003467071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001774361,"about_ca_topic_score_gemma":0.00118025,"domain_scores_codex":[0.9917343,0.002582726,0.003617123,0.0008543232,0.0004358742,0.0007756886],"domain_scores_gemma":[0.9903969,0.007514829,0.0007596157,0.000839381,0.0001908245,0.0002984648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7522214,0.001158542,0.001446456,0.00004311518,0.0001848652,0.00009708759,0.0003785145,5.973769e-7,0.00009418154,0.005138355,0.00005007681,0.2391868],"study_design_scores_gemma":[0.9825434,0.01260015,0.00006632644,0.000869551,0.0001491483,0.0006680998,0.0004929103,0.0001852518,0.0002043835,0.0008847096,0.001041172,0.000294908],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717154,0.01013448,0.00009625729,0.00171211,0.001490433,0.01307743,0.00001797123,0.00008262232,0.001673282],"genre_scores_gemma":[0.9903761,0.007879601,0.0002478159,0.0001677753,0.00007429456,0.000828281,0.00006758809,0.00005014453,0.0003084522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2388919,"threshold_uncertainty_score":0.9998923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660425493043886,"score_gpt":0.3191045873091085,"score_spread":0.2925003323786696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}