{"id":"W2949458789","doi":"10.1002/chin.200309132","title":"Targeting Thrombin and Factor VIIa: Design, Synthesis, and Inhibitory Activity of Functionally Relevant Indolizidinones.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Factor VIIa; Inhibitory postsynaptic potential; Thrombin; Stereochemistry; Pharmacology; Combinatorial chemistry; Tissue factor; Coagulation; Platelet; Internal medicine; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900575,0.0005028098,0.000229879,0.0001904545,0.0001295068,0.0002632863,0.0004715842,0.0002963352,0.001605559],"category_scores_gemma":[0.0001743057,0.0001676534,0.0002062377,0.0001235653,0.0001937448,0.0002800515,0.0001538136,0.0005516192,0.0008947943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003976657,"about_ca_system_score_gemma":0.0002651277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004321824,"about_ca_topic_score_gemma":0.0009549132,"domain_scores_codex":[0.9999279,0.00001778915,0.000004933908,0.0000131895,0.00001725465,0.0000189162],"domain_scores_gemma":[0.9999571,0.000006757634,0.00001177198,0.000004443645,0.000007616878,0.00001222243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003673621,0.00008611356,0.0001057841,0.0001715631,0.00001178124,0.0001502599,0.00003830139,0.0006603916,0.9778069,0.001380168,0.0004107651,0.01881061],"study_design_scores_gemma":[0.0001550224,0.001085284,0.0005687225,0.00002088278,0.0000470999,0.0007588551,0.0000212513,0.0007713076,0.9703107,0.0004251582,0.02582298,0.00001280784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8649722,0.06060634,0.045227,0.001524942,0.000249561,0.00042478,0.001213167,0.0004158884,0.02536605],"genre_scores_gemma":[0.9499416,0.02026813,0.01851399,0.0002717619,0.0000535085,0.0001355703,0.001027013,0.00005186865,0.009736384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605559,"threshold_uncertainty_score":0.005371153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213058178325176,"score_gpt":0.22090082092046,"score_spread":0.1995950030879424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}