{"id":"W2949458789","doi":"10.1002/chin.200309132","title":"Targeting Thrombin and Factor VIIa: Design, Synthesis, and Inhibitory Activity of Functionally Relevant Indolizidinones.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Factor VIIa; Inhibitory postsynaptic potential; Thrombin; Stereochemistry; Pharmacology; Combinatorial chemistry; Tissue factor; Coagulation; Platelet; Internal medicine; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000192734,0.0001711809,0.0002543099,0.00003838821,0.0001051058,0.00002642555,0.0000603339,0.0001545006,0.00046933],"category_scores_gemma":[0.0006729562,0.0001515957,0.00005215855,0.00006133251,0.0001312318,0.0002053524,0.00003780398,0.0001502966,0.000004691453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005872031,"about_ca_system_score_gemma":0.0000891571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001499461,"about_ca_topic_score_gemma":7.017525e-7,"domain_scores_codex":[0.9991615,0.00000159808,0.0002482202,0.0002136651,0.0001848406,0.0001901072],"domain_scores_gemma":[0.9989461,0.0005386245,0.0001751397,0.0001915553,0.00005389757,0.00009469765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003107201,0.00006920128,0.0008001621,0.0002076868,0.00006867987,0.000001360435,0.0002353764,4.641218e-7,0.9603245,0.0001538389,0.000870591,0.0372371],"study_design_scores_gemma":[0.0002085083,0.000008788486,0.001507842,0.00006530635,0.000036571,0.00003698354,0.0004448785,0.00001533775,0.9939894,0.0001004887,0.003418912,0.0001669815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8864732,0.0006791135,0.00004559268,0.00003481586,0.00007419605,0.00009440316,0.00002559003,0.00004879842,0.1125242],"genre_scores_gemma":[0.9985375,0.0002885054,0.0001689051,0.000009341046,0.00004664318,0.00002857336,0.000003909641,0.00001738312,0.0008992093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120643,"threshold_uncertainty_score":0.6181895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213058178325176,"score_gpt":0.22090082092046,"score_spread":0.1995950030879424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}