{"id":"W2949512078","doi":"10.1097/01.hs9.0000563628.38037.c3","title":"PS1337 IVOSIDENIB (AG‐120) INDUCES DURABLE REMISSIONS AND TRANSFUSION INDEPENDENCE IN PATIENTS WITH IDH1‐MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME IN A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; Medicine; IDH1; Internal medicine; Myelodysplastic syndromes; Refractory (planetary science); Myeloid leukemia; Bone marrow; Gastroenterology; Oncology; Pharmacodynamics; Pharmacokinetics; International Prognostic Scoring System; Mutant; Chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008221239,0.001012779,0.001040559,0.0003977663,0.0002801952,0.0006436221,0.0005755482,0.0005528358,0.002125879],"category_scores_gemma":[0.0004067445,0.0003484988,0.0005449844,0.0002939409,0.000548139,0.0005050681,0.0002630767,0.002535927,0.0004487555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000693812,"about_ca_system_score_gemma":0.001000272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005461947,"about_ca_topic_score_gemma":0.0016099,"domain_scores_codex":[0.9997846,0.00008538253,0.00001248347,0.00003570938,0.00002835871,0.00005342012],"domain_scores_gemma":[0.9996948,0.00004954514,0.00005599196,0.00003169238,0.00001991655,0.0001480295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2885802,0.116309,0.01284873,0.001006054,0.001529861,0.0005681046,0.0007849737,0.006381274,0.2610751,0.0007473308,0.01189861,0.2982708],"study_design_scores_gemma":[0.2609325,0.6581097,0.03537458,0.0000741502,0.0007273408,0.0008523762,0.0001300788,0.004260095,0.03130585,0.0004483115,0.007730793,0.0000543183],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968726,0.0007306885,0.0002885924,0.0001840505,0.00003309298,0.0004658543,0.0003394845,0.00009883754,0.0009869846],"genre_scores_gemma":[0.9957191,0.000616631,0.0008000967,0.0002948724,0.00004803992,0.0003780749,0.001051946,0.00002042174,0.001070733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125879,"threshold_uncertainty_score":0.007111788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147663653771724,"score_gpt":0.2696218567481647,"score_spread":0.2581452202104475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}