{"id":"W2949512078","doi":"10.1097/01.hs9.0000563628.38037.c3","title":"PS1337 IVOSIDENIB (AG‐120) INDUCES DURABLE REMISSIONS AND TRANSFUSION INDEPENDENCE IN PATIENTS WITH IDH1‐MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME IN A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; Medicine; IDH1; Internal medicine; Myelodysplastic syndromes; Refractory (planetary science); Myeloid leukemia; Bone marrow; Gastroenterology; Oncology; Pharmacodynamics; Pharmacokinetics; International Prognostic Scoring System; Mutant; Chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047089,0.0002938394,0.0005442764,0.0002877232,0.00009644003,0.00003747329,0.0001015681,0.0002701322,0.0004142187],"category_scores_gemma":[0.0001801528,0.0002249355,0.00002366136,0.0006443972,0.0000796114,0.0004884906,0.00009299112,0.000965067,0.00002154113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205986,"about_ca_system_score_gemma":0.0003269291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004515342,"about_ca_topic_score_gemma":0.0004509478,"domain_scores_codex":[0.9973524,0.0001733764,0.0004971059,0.0007152886,0.0008287158,0.000433092],"domain_scores_gemma":[0.9988619,0.0002369073,0.0001106371,0.0003969061,0.0001183214,0.0002753278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004064885,0.002262466,0.9236192,0.0002962887,0.00003304319,0.0006402379,0.003044613,0.00002998872,0.06045764,0.000006293348,0.00002059992,0.005524769],"study_design_scores_gemma":[0.03147829,0.004720445,0.9567696,0.001498038,0.00005497903,0.0001365691,0.00309686,0.0009280376,0.0009846793,0.00002673086,0.00001824354,0.0002875437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967327,0.0001971285,0.00001611313,0.0001300924,0.00005345433,0.002616527,0.000007055497,0.00003821689,0.0002087283],"genre_scores_gemma":[0.9992294,0.0001462151,0.0001774249,0.00003248387,0.00001286473,0.00006629663,0.00002461622,0.00004762027,0.0002631042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05947296,"threshold_uncertainty_score":0.9172605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147663653771724,"score_gpt":0.2696218567481647,"score_spread":0.2581452202104475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}