{"id":"W2949545493","doi":"10.1021/ol702509a","title":"Oxidative Decarboxylation as a Route to Ketene Acetals:  Assignment of Relative and Absolute Stereochemistry to the Fungal Metabolite Benesudon by Total Synthesis","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketene; Chemistry; Oxidative decarboxylation; Acetal; Metabolite; Decarboxylation; Stereochemistry; Ring (chemistry); Absolute configuration; Total synthesis; Oxidative phosphorylation; Absolute (philosophy); Medicinal chemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004080995,0.0005479533,0.0003350916,0.0003884512,0.0004244962,0.0004827936,0.000402935,0.000276955,0.001405933],"category_scores_gemma":[0.0003071782,0.0002090851,0.0003106212,0.0004740773,0.0004501703,0.0004997934,0.0004344033,0.0007106115,0.0005378085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003712518,"about_ca_system_score_gemma":0.0008166074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006719637,"about_ca_topic_score_gemma":0.001478103,"domain_scores_codex":[0.9997767,0.00003634384,0.00001754424,0.00004640232,0.00003890522,0.00008425074],"domain_scores_gemma":[0.9998044,0.00002338702,0.00003208716,0.00003825821,0.00004952322,0.00005231577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000700761,0.00007181584,0.0007098583,0.0002387758,0.00002966228,0.000667034,0.0002563102,0.000900383,0.9555793,0.006324871,0.0003079773,0.03421331],"study_design_scores_gemma":[0.00005420347,0.0007830934,0.00132961,0.00001896655,0.00003784485,0.000575577,0.0001086843,0.0006103971,0.9846672,0.000963593,0.01080664,0.00004429185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8868116,0.004723576,0.08675762,0.0003879674,0.0004486213,0.000221159,0.0009171381,0.0002959669,0.01943633],"genre_scores_gemma":[0.9756825,0.002548817,0.0180764,0.0000649657,0.00003339431,0.00003673045,0.0004004578,0.00003694073,0.00311978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405933,"threshold_uncertainty_score":0.004703283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004559865805080064,"score_gpt":0.2214233590924344,"score_spread":0.2168634932873544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}