{"id":"W2949549550","doi":"10.1016/j.ecoenv.2019.06.003","title":"Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα)","year":2019,"lang":"en","type":"article","venue":"Ecotoxicology and Environmental Safety","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"China Postdoctoral Science Foundation; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Peroxisome proliferator-activated receptor; Peroxisome; Fatty acid; Fatty acid metabolism; Chlorinated paraffins; Metabolism; Chemistry; In silico; Biochemistry; Nuclear receptor; Receptor; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000201473,0.0002640226,0.0004482144,0.0000636921,0.0000828965,0.000007459492,0.0001191641,0.0001945746,0.0003393799],"category_scores_gemma":[0.00002321474,0.0002233425,0.00007258427,0.00009318317,0.0001774425,0.00001965537,0.0002125921,0.0002105524,0.00001349433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004964942,"about_ca_system_score_gemma":0.00001397762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001133208,"about_ca_topic_score_gemma":0.00007183983,"domain_scores_codex":[0.9986241,0.0001193565,0.0003406053,0.0004860554,0.00009595037,0.000333884],"domain_scores_gemma":[0.9995077,0.00003572431,0.0001359352,0.0002355602,0.000008152677,0.00007687731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008937966,0.0002359419,0.1811014,0.00002682379,0.0001551716,0.000005988433,0.000129257,0.00005237858,0.8163922,0.00002620574,0.00001058443,0.0009701871],"study_design_scores_gemma":[0.001328369,0.0006966397,0.2306449,0.00001889165,0.00003986543,0.000045145,0.0003679739,0.0001623975,0.7643138,0.00000646185,0.002066412,0.0003092223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976207,0.001208074,0.0000962959,0.00005967843,0.0001942115,0.0005439215,0.00004541888,0.000007073034,0.0002246071],"genre_scores_gemma":[0.9969545,0.002055992,0.0004230878,0.00008145158,0.00004477013,0.00005943751,0.0001485672,0.00002568369,0.0002065124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05207853,"threshold_uncertainty_score":0.9107645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004834846764784339,"score_gpt":0.1995922310631695,"score_spread":0.1947573842983852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}