{"id":"W2949582358","doi":"10.1371/journal.ppat.1007220","title":"The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation of Korea","keywords":"Cryptococcus neoformans; Biology; Mutant; Virulence; Endocytic cycle; Cell biology; Endocytosis; Mitochondrion; Cryptococcosis; Vacuole; Microbiology; Fungal protein; Transferrin; Biochemistry; Cell; Cytoplasm; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009860341,0.0002857121,0.000195729,0.0001828402,0.000168729,0.000343345,0.0001278004,0.0003206166,0.0003260893],"category_scores_gemma":[0.0001121607,0.0001303352,0.0002965907,0.0001544152,0.0001730131,0.0001635122,0.0002087782,0.0002361234,0.0001471701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003409268,"about_ca_system_score_gemma":0.0001560363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571396,"about_ca_topic_score_gemma":0.0009937652,"domain_scores_codex":[0.9998853,0.00001520759,0.00001705568,0.00002012299,0.00003894672,0.0000233245],"domain_scores_gemma":[0.9999059,0.00001097836,0.00003944633,0.000008574284,0.000009148665,0.00002591067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004574741,0.000009146585,0.0007493547,0.00001106744,0.000003201904,0.0001092903,0.00001163832,0.00007119684,0.9984744,0.00004474862,0.000006668093,0.0004635912],"study_design_scores_gemma":[0.000006666159,0.0001459199,0.02630168,0.000007964382,0.00002136343,0.001289601,0.00009085064,0.001794594,0.9694513,0.00006030111,0.0008242551,0.000005484907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989281,0.0002774268,0.0005024894,0.00002654451,0.000003422442,0.000003636267,0.00006681728,0.00001042884,0.0001810399],"genre_scores_gemma":[0.998844,0.0001156427,0.0006363698,0.00001357184,9.985542e-7,0.000002510114,0.0001042472,0.000004424164,0.0002782293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571396,"threshold_uncertainty_score":0.003124535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401475001323617,"score_gpt":0.249676598355604,"score_spread":0.2256618483423678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}