{"id":"W2949585116","doi":"10.1371/journal.pone.0218103","title":"Statistical methods for classification of 5hmC levels based on the Illumina Inifinium HumanMethylation450 (450k) array data, under the paired bisulfite (BS) and oxidative bisulfite (oxBS) treatment","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Bundesministerium für Bildung und Forschung","keywords":"Bisulfite; DNA methylation; Epigenetics; Computational biology; Bisulfite sequencing; Methylation; Pairwise comparison; Biology; Genetics; Gene; Computer science; Gene expression; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0215493,0.001161342,0.001467977,0.005874938,0.000748254,0.001572629,0.002202701,0.00130134,0.002613133],"category_scores_gemma":[0.05917366,0.0004851822,0.001983064,0.004850694,0.001384601,0.001340296,0.001772943,0.002431692,0.0009839723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008951055,"about_ca_system_score_gemma":0.0009083386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247969,"about_ca_topic_score_gemma":0.001273293,"domain_scores_codex":[0.9834318,0.009113246,0.001510646,0.002938975,0.002795018,0.0002103691],"domain_scores_gemma":[0.9545922,0.03442133,0.003802559,0.005204609,0.001729845,0.0002494889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001494998,0.0004184186,0.09764878,0.002358284,0.004779851,0.0003625911,0.0009709949,0.07477272,0.04588721,0.03554407,0.007733083,0.728029],"study_design_scores_gemma":[0.0001069557,0.00112273,0.08964423,0.0002390392,0.000510137,0.0009121953,0.0004571848,0.8121786,0.02577163,0.05635433,0.01250694,0.0001960516],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.02662017,0.0005051194,0.9693285,0.0001134112,0.00004875502,0.0002737214,0.001334195,0.001244979,0.000531061],"genre_scores_gemma":[0.207534,0.0003240159,0.785245,0.0001206242,0.00008496321,0.001843493,0.003743106,0.0004816565,0.0006232047],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0215493,"threshold_uncertainty_score":0.113965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1798066737280426,"score_gpt":0.3599603502888417,"score_spread":0.1801536765607991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}