{"id":"W2949598754","doi":"10.1016/b978-0-08-095167-6.00104-x","title":"1.6 Peptides and Chirality Effects on the Conformation and the Synthesis of Medicinally Relevant Peptides","year":2012,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Theratechnologies (Canada); Université de Montréal","funders":"","keywords":"Racemization; Chirality (physics); Diastereomer; Enantiomer; Peptide; Stereochemistry; Amino acid; Function (biology); Sequence (biology); Chemistry; Combinatorial chemistry; Biochemistry; Biology; Physics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006985806,0.0002486094,0.0004242038,0.00002571104,0.0001050315,0.00001705263,0.0001552305,0.0001998676,0.00001678751],"category_scores_gemma":[0.0003047395,0.0001224653,0.0001958322,0.000006230024,0.000538851,0.000002185763,0.0001228153,0.0001639302,0.000003593361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007562916,"about_ca_system_score_gemma":0.00001774609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002781093,"about_ca_topic_score_gemma":0.000008444016,"domain_scores_codex":[0.9990369,0.00007824276,0.0003212587,0.0002201226,0.0002001036,0.0001433909],"domain_scores_gemma":[0.9987162,0.0004881932,0.0002935755,0.0003883245,0.00005190086,0.00006175465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001068795,0.000005758808,0.00003033919,0.0001812078,0.0003346581,4.546832e-7,0.0001072892,6.291232e-8,0.01611679,0.004660351,0.0001090016,0.9783472],"study_design_scores_gemma":[0.0008415939,0.0002017276,0.0008484149,0.001583797,0.001773244,0.00002361837,0.00008820976,0.00001861524,0.3515383,0.006761017,0.6356652,0.0006562052],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.09062919,0.01044334,0.000003986951,0.001131761,0.00004911964,0.0006545114,0.00003757471,0.000009308676,0.8970412],"genre_scores_gemma":[0.9153391,0.003944968,0.00003894913,0.0006308428,0.0003125058,0.00004762225,0.00001726852,0.00003120403,0.07963759],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.977691,"threshold_uncertainty_score":0.499399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006893662629236241,"score_gpt":0.2068477731412961,"score_spread":0.1999541105120598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}