{"id":"W2949612666","doi":"10.1101/150623","title":"Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimer’s disease like pathology","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; National Institutes of Health; Northwestern University","keywords":"Proteome; Genetically modified mouse; AMPA receptor; Biology; Neuroscience; Apolipoprotein E; Transgene; Proteomics; Neurodegeneration; Amyloid precursor protein; Cell biology; Pathology; Receptor; Alzheimer's disease; Disease; Medicine; Bioinformatics; Glutamate receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075536,0.0006825438,0.0004087978,0.001523032,0.0003466258,0.000680118,0.0002406849,0.0005045624,0.001687087],"category_scores_gemma":[0.0001884049,0.000385896,0.0006802243,0.0006816072,0.0003411284,0.0003089163,0.0004004324,0.001010478,0.0006223304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003680333,"about_ca_system_score_gemma":0.000222696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007474095,"about_ca_topic_score_gemma":0.00115536,"domain_scores_codex":[0.9996705,0.00002720286,0.00004764149,0.00009336116,0.0001038744,0.0000573473],"domain_scores_gemma":[0.9995994,0.000030779,0.0001663775,0.00004055226,0.00007251788,0.0000903464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00023252,0.00004925517,0.0008588984,0.00004053637,0.00003435173,0.0001191148,0.00003709174,0.00006465227,0.9975815,0.00006613958,0.0001206977,0.0007952831],"study_design_scores_gemma":[0.00007665797,0.0009858382,0.1126637,0.0000710626,0.0002635129,0.004059393,0.0002976583,0.002866006,0.8698508,0.0006703501,0.008151519,0.00004361205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851359,0.001430598,0.005634512,0.0001533491,0.0000548626,0.00006963874,0.006102929,0.0002787739,0.001139647],"genre_scores_gemma":[0.9733142,0.00204176,0.00792529,0.0002802405,0.00002490768,0.0002822764,0.0108671,0.0002211962,0.005042875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687087,"threshold_uncertainty_score":0.005643845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05676647760252216,"score_gpt":0.3144434977131121,"score_spread":0.25767702011059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}