{"id":"W2949615151","doi":"10.1101/254490","title":"A genetically encoded biosensor reveals location bias of opioid drug action","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Internalization; Endosome; Golgi apparatus; Receptor; Neuroscience; Cell biology; Chemistry; Peptide; Opioid peptide; Neuromodulation; Biology; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361799,0.0001814707,0.0001577825,0.0001545675,0.00009863641,0.0003129256,0.0003301298,0.0004630873,0.0007966947],"category_scores_gemma":[0.0002073765,0.0001476052,0.0001778694,0.0001000474,0.000327989,0.0001693686,0.000230084,0.0005892686,0.0003211455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005480136,"about_ca_system_score_gemma":0.0002341751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005462947,"about_ca_topic_score_gemma":0.000596679,"domain_scores_codex":[0.9998757,0.00001105499,0.000007224764,0.00004318024,0.00003851292,0.00002432721],"domain_scores_gemma":[0.9998847,0.000034381,0.00003812255,0.00001250896,0.00001369451,0.00001649631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001272335,0.000005875886,0.00005319142,0.000004946855,8.481906e-7,0.00001231268,0.000003686052,0.00006252508,0.9991376,0.0001813864,0.00001730615,0.0005075024],"study_design_scores_gemma":[0.000005630151,0.00003103214,0.0006224268,0.000001735085,0.000003430825,0.00006583818,0.000007821381,0.002123866,0.9962606,0.00009382924,0.0007799263,0.000003914338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786348,0.000355575,0.01780377,0.0003328571,0.00007971455,0.0000191289,0.00025993,0.0001897395,0.002324566],"genre_scores_gemma":[0.9787459,0.0003178521,0.01707424,0.0001155785,0.00001125734,0.00002257427,0.0002019622,0.00004331927,0.00346733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007966947,"threshold_uncertainty_score":0.003976166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156481458568562,"score_gpt":0.243650327666797,"score_spread":0.2220855130811114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}