{"id":"W2949627837","doi":"10.1002/adma.201901051","title":"Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon","year":2019,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Juvenile Diabetes Research Foundation Canada","keywords":"Hypoglycemia; Glucagon; Insulin; Transdermal; Phenylboronic acid; Diabetes mellitus; Medicine; Internal medicine; Endocrinology; Materials science; Pharmacology; Chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006025418,0.0003852129,0.0007566684,0.0001552232,0.0001490391,0.00001118738,0.000402912,0.0003233312,0.001529193],"category_scores_gemma":[0.00009877085,0.0003960491,0.0001508788,0.0001710548,0.0002155404,0.0003497363,0.0001208602,0.0002578948,0.0002205772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772376,"about_ca_system_score_gemma":0.0001244643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002686053,"about_ca_topic_score_gemma":0.000004911856,"domain_scores_codex":[0.9974286,0.0003793446,0.0007822773,0.0005404703,0.0002468291,0.0006224568],"domain_scores_gemma":[0.997288,0.001198419,0.0004815793,0.000349743,0.0005483977,0.0001338936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01080534,0.0002776378,0.0002094559,0.000343245,0.0002829685,0.00001021144,0.0005364675,0.001754528,0.9789877,0.0003965276,0.0003672944,0.006028656],"study_design_scores_gemma":[0.006090607,0.0004393084,0.0001934005,0.00007413932,0.0001468522,0.000008958603,0.0002644716,0.0001043476,0.9442581,0.0008615393,0.04716228,0.0003959728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892482,0.001298776,0.001051337,0.00009713822,0.003347174,0.002180164,0.001954057,0.00008978422,0.0007333786],"genre_scores_gemma":[0.9903538,0.00105349,0.006033077,0.0009354707,0.0001381204,0.0002283274,0.0002318183,0.00007013101,0.0009557157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04679498,"threshold_uncertainty_score":0.9998491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0488029815669964,"score_gpt":0.3931102932876078,"score_spread":0.3443073117206114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}