{"id":"W2949712711","doi":"10.1101/gr.257576.119","title":"Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors","year":2020,"lang":"en","type":"article","venue":"Genome Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Ludwig Institute for Cancer Research; Medical Research Council Canada; Cancer Research UK; Wellcome Trust; Conrad N. Hilton Foundation","keywords":"Biology; Epigenetics of physical exercise; DNA methylation; Epigenomics; Chromatin; Epigenetics; Pioneer factor; Histone methylation; Histone code; Histone; Transcription coregulator; Genetics; Histone methyltransferase; Chromatin remodeling; Cell biology; Gene expression; Nucleosome; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002984919,0.0002426017,0.0002690904,0.0003643989,0.0001373029,0.000549656,0.0002827777,0.000228777,0.0008728818],"category_scores_gemma":[0.000441327,0.0002693322,0.0002409972,0.0001849561,0.0005410438,0.0003101746,0.0003116044,0.0003738003,0.0002412438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331933,"about_ca_system_score_gemma":0.0002128378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009836855,"about_ca_topic_score_gemma":0.002169388,"domain_scores_codex":[0.9996864,0.00003918533,0.00002019994,0.00009370694,0.0001011475,0.00005934122],"domain_scores_gemma":[0.9997814,0.00004890906,0.00005361225,0.00002974927,0.00003111121,0.00005517952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008190344,0.000004552463,0.001823635,0.00001870582,0.00001045376,0.0000133501,0.0000176966,0.00004998027,0.9958134,0.0001959787,0.000006259882,0.001964073],"study_design_scores_gemma":[0.00001724311,0.0002498335,0.1685376,0.00001508761,0.00005891639,0.0002632281,0.0001404272,0.001479782,0.8273674,0.0005252988,0.001324829,0.00002038583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880669,0.004777639,0.00490506,0.0001001534,0.00002632045,0.000009220811,0.0002166604,0.00003593533,0.00186218],"genre_scores_gemma":[0.9968675,0.001104109,0.001051635,0.00003171972,0.00001198782,0.000008250417,0.0001655719,0.000009884056,0.0007492951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009836855,"threshold_uncertainty_score":0.002920091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06541522726961099,"score_gpt":0.3685825541409812,"score_spread":0.3031673268713703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}