{"id":"W2949712711","doi":"10.1101/gr.257576.119","title":"Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors","year":2020,"lang":"en","type":"article","venue":"Genome Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Ludwig Institute for Cancer Research; Medical Research Council Canada; Cancer Research UK; Wellcome Trust; Conrad N. Hilton Foundation","keywords":"Biology; Epigenetics of physical exercise; DNA methylation; Epigenomics; Chromatin; Epigenetics; Pioneer factor; Histone methylation; Histone code; Histone; Transcription coregulator; Genetics; Histone methyltransferase; Chromatin remodeling; Cell biology; Gene expression; Nucleosome; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006887443,0.00007356609,0.000122898,0.00006560831,0.0001110094,0.00001026191,0.000124604,0.00007911122,0.00001473913],"category_scores_gemma":[0.0003318189,0.00005953986,0.00004825287,0.0002438084,0.00009924429,0.000003925593,0.00007162361,0.0000886288,0.000002926713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002494733,"about_ca_system_score_gemma":0.00006536362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005042506,"about_ca_topic_score_gemma":0.00002807705,"domain_scores_codex":[0.9989654,0.000199254,0.0002417508,0.000209345,0.0002227388,0.0001615515],"domain_scores_gemma":[0.9993004,0.00004838843,0.00006924841,0.0001852893,0.0003044751,0.00009215956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007677311,0.00001621481,0.002021886,0.00002732609,0.00002220275,6.000872e-8,0.0006704014,0.0001377672,0.995216,0.0001511372,0.00002106344,0.001639241],"study_design_scores_gemma":[0.0002446519,0.0004219158,0.2106074,0.000003885723,0.00001469246,1.394058e-7,0.0001570127,0.0001313827,0.7776553,0.0001251179,0.01057017,0.00006828282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786603,0.003285869,0.01633853,0.001018622,0.00002627243,0.0003893373,0.0001431225,0.000003178988,0.000134714],"genre_scores_gemma":[0.999015,0.0004206537,0.0002043393,0.00001108993,0.00008830566,0.00001198918,0.0001988075,0.000009840122,0.00003999858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2175606,"threshold_uncertainty_score":0.2427965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06541522726961099,"score_gpt":0.3685825541409812,"score_spread":0.3031673268713703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}