{"id":"W2949718907","doi":"10.1016/j.sbi.2019.06.001","title":"The role of water in amyloid aggregation kinetics","year":2019,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Alzheimer’s Research UK; Medical Research Council Canada; Wellcome Trust","keywords":"Intrinsically disordered proteins; Osmolyte; Chemistry; Biophysics; Hydrogen bond; Globular protein; Protein aggregation; Fibril; Amyloid fibril; Amyloid (mycology); Protein folding; Intermolecular force; Kinetics; Crystallography; Amyloid β; Biochemistry; Biology; Molecule; Disease; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023708,0.0002434106,0.0008818877,0.0002115822,0.00002356061,0.000007271753,0.0001692796,0.0002057515,0.00004450919],"category_scores_gemma":[0.00004695068,0.0001114706,0.0002014179,0.0001652324,0.0001580003,0.00002290494,0.0001067517,0.0003712805,0.00005524457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308294,"about_ca_system_score_gemma":0.0001457523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002167546,"about_ca_topic_score_gemma":0.000002950194,"domain_scores_codex":[0.9983962,0.0002362552,0.0005768834,0.0002913918,0.0001348309,0.0003644256],"domain_scores_gemma":[0.9992535,0.0001449502,0.0001631067,0.0003079532,0.00005730463,0.00007319967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000501587,0.00003632281,0.004084378,0.003617262,0.0003434512,6.300422e-7,0.00002113786,1.581836e-7,0.000002718524,0.0003543961,0.00001498995,0.9914744],"study_design_scores_gemma":[0.00110484,0.0003568628,0.001698132,0.007776491,0.0002418169,0.00002631939,0.00001896662,0.00002444788,0.0000413644,0.001570785,0.986941,0.0001989316],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001396498,0.995758,1.756674e-7,0.0000246804,0.001576479,0.001093456,0.00008303229,0.000006324646,0.00006134609],"genre_scores_gemma":[0.01307842,0.9845051,0.000007137543,0.000001057953,0.0001850066,0.00007674435,0.002127383,0.00001499736,0.000004149211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912755,"threshold_uncertainty_score":0.4545639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08626180501801915,"score_gpt":0.4246769794197794,"score_spread":0.3384151744017603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}