{"id":"W2949744056","doi":"10.1081/ncn-100002317","title":"PROPERTIES OF ARABINONUCLEIC ACIDS (ANA & 20′F-ANA): IMPLICATIONS FOR THE DESIGN OF ANTISENSE THERAPEUTICS THAT INVOKE RNASE H CLEAVAGE OF RNA","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"","keywords":"RNA; RNase H; Cleavage (geology); RNase P; Nucleic acid structure; Nucleic acid; Chemistry; Molecular biology; Stereochemistry; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009159088,0.0005023542,0.0007320134,0.0001617293,0.0003122169,0.00005044611,0.001114734,0.0003617666,0.00005208706],"category_scores_gemma":[0.0002443619,0.000384688,0.0005233175,0.0003468585,0.0008655844,0.00004268865,0.0002435346,0.0001699138,0.00001052951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862506,"about_ca_system_score_gemma":0.0001534615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007547018,"about_ca_topic_score_gemma":0.00004401473,"domain_scores_codex":[0.9971459,0.0002762542,0.0009880961,0.0006273608,0.0003690803,0.0005933024],"domain_scores_gemma":[0.9969014,0.0002381739,0.0008289688,0.001460024,0.0004333287,0.0001381228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008342496,0.0002790926,0.002364966,0.0001636872,0.0004493598,0.000001043072,0.0003771345,0.0002021532,0.9793512,0.001071283,0.001254749,0.01365106],"study_design_scores_gemma":[0.0008752484,0.0006940243,0.004556623,0.0001637685,0.0003653259,0.0000334772,0.0005343005,0.0002119188,0.9749792,0.001174706,0.01597241,0.0004389534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673162,0.00395479,0.0249944,0.001026439,0.0001823227,0.001750778,0.0001747962,0.00005273408,0.0005475268],"genre_scores_gemma":[0.9837498,0.003603593,0.01155873,0.0004129065,0.0001342603,0.0001072068,0.00002385648,0.0001548066,0.0002548192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01643361,"threshold_uncertainty_score":0.9998605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822507057822734,"score_gpt":0.2727889524732721,"score_spread":0.2045638818950448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}