{"id":"W2949744056","doi":"10.1081/ncn-100002317","title":"PROPERTIES OF ARABINONUCLEIC ACIDS (ANA & 20′F-ANA): IMPLICATIONS FOR THE DESIGN OF ANTISENSE THERAPEUTICS THAT INVOKE RNASE H CLEAVAGE OF RNA","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"","keywords":"RNA; RNase H; Cleavage (geology); RNase P; Nucleic acid structure; Nucleic acid; Chemistry; Molecular biology; Stereochemistry; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045967,0.0003788925,0.0002179946,0.0002704952,0.0001834208,0.0006034499,0.0001658399,0.0005042453,0.0005484719],"category_scores_gemma":[0.0002962411,0.00019094,0.0001692893,0.0001214259,0.0003514679,0.0005315377,0.0001132007,0.0004315651,0.000328106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003240288,"about_ca_system_score_gemma":0.0001487003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002383189,"about_ca_topic_score_gemma":0.0002813173,"domain_scores_codex":[0.9998661,0.00003552499,0.000009164892,0.00003065693,0.00003943397,0.00001907209],"domain_scores_gemma":[0.9998009,0.00007735076,0.00006027204,0.000008827212,0.00002438759,0.0000281936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003644478,0.00001425812,0.0002721614,0.0001196821,0.000006082175,0.0001133847,0.00005673735,0.0002626746,0.9876477,0.002539111,0.00004793249,0.008883802],"study_design_scores_gemma":[0.000005446942,0.0004257054,0.001751849,0.00001033232,0.0000148652,0.001372181,0.00004120661,0.000581842,0.9794419,0.00116493,0.01517509,0.00001457366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8439928,0.0865967,0.04045723,0.0006754243,0.0001532947,0.00008388657,0.000214191,0.0001373044,0.02768913],"genre_scores_gemma":[0.9656811,0.01567922,0.01313491,0.0001827897,0.0000994755,0.00005183395,0.000116921,0.0000277984,0.005025932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006034499,"threshold_uncertainty_score":0.002350986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822507057822734,"score_gpt":0.2727889524732721,"score_spread":0.2045638818950448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}