{"id":"W2949772843","doi":"10.1021/jo0506938","title":"Substitution of Hydroxybiaryls via Directed <i>o</i><i>rtho</i>-Lithiation of <i>N</i>-Silylated <i>O</i>-Aryl <i>N</i>-Isopropylcarbamates","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Aryl; Metalation; Regioselectivity; Reagent; Electrophile; Medicinal chemistry; Silylation; Electrophilic substitution; Isopropyl; Substitution reaction; Bond cleavage; Ether; Phenols; Isocyanate; Organic chemistry; Coupling reaction; Alkyl; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113699,0.0004269353,0.0001729089,0.0001385818,0.00008595531,0.0001703987,0.0003231742,0.0001553191,0.001312921],"category_scores_gemma":[0.0001058376,0.0001382578,0.000136582,0.0001380392,0.0001507795,0.0002919423,0.0002866395,0.0002906822,0.0006617277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756752,"about_ca_system_score_gemma":0.0001639913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003073346,"about_ca_topic_score_gemma":0.0008574912,"domain_scores_codex":[0.9999082,0.00001547243,0.000009471015,0.00002070263,0.00001755364,0.00002861543],"domain_scores_gemma":[0.9999279,0.000006442545,0.0000347969,0.00001155537,0.000006525143,0.00001270324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009611152,0.00002031231,0.0001040329,0.00007097803,0.000006212558,0.00008024768,0.00003260025,0.0001229951,0.995837,0.000415122,0.00006603405,0.003148434],"study_design_scores_gemma":[0.000005610068,0.000135848,0.0003215646,0.000003049676,0.000006912555,0.0001030503,0.000005341425,0.0001764278,0.9974174,0.00001711649,0.001804153,0.000003437257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981133,0.00143461,0.008899337,0.0000678147,0.00004459199,0.00004425721,0.0002395554,0.0002069109,0.007929896],"genre_scores_gemma":[0.9914624,0.001100947,0.003787277,0.0000400713,0.000009500049,0.00002392644,0.0002110624,0.00004740286,0.00331749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312921,"threshold_uncertainty_score":0.004392147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006049211095765106,"score_gpt":0.2046755701390787,"score_spread":0.1986263590433136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}