{"id":"W2949772843","doi":"10.1021/jo0506938","title":"Substitution of Hydroxybiaryls via Directed <i>o</i><i>rtho</i>-Lithiation of <i>N</i>-Silylated <i>O</i>-Aryl <i>N</i>-Isopropylcarbamates","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Aryl; Metalation; Regioselectivity; Reagent; Electrophile; Medicinal chemistry; Silylation; Electrophilic substitution; Isopropyl; Substitution reaction; Bond cleavage; Ether; Phenols; Isocyanate; Organic chemistry; Coupling reaction; Alkyl; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009319317,0.000376351,0.0007142301,0.00006382401,0.0001251745,0.00002182383,0.0008944293,0.000325971,0.004116729],"category_scores_gemma":[0.0004708162,0.000303692,0.0003323969,0.0007338086,0.0003232329,0.0003399373,0.0001344569,0.0006631842,0.000008480903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752327,"about_ca_system_score_gemma":0.0003141153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001100396,"about_ca_topic_score_gemma":0.000003289944,"domain_scores_codex":[0.9968102,0.00004332377,0.001767226,0.0002334349,0.0008077167,0.0003380711],"domain_scores_gemma":[0.9955001,0.0003614513,0.002422603,0.0006644535,0.0008852077,0.0001661391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411128,0.0003600682,0.001319552,0.0005218195,0.000234575,0.000003478741,0.0003760018,0.0002359091,0.9949573,0.000008369122,0.000242404,0.001499378],"study_design_scores_gemma":[0.001320905,0.0000313403,0.0002063336,0.000225451,0.0003865495,0.0003429301,0.0001613674,0.0003965349,0.9938778,0.0001657163,0.002604458,0.0002805713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993049,0.001951685,0.0006347947,0.0005171914,0.0001037288,0.00007762208,0.00004070779,0.00007766193,0.003547643],"genre_scores_gemma":[0.9976375,0.0006881636,0.0004700432,0.00005155654,0.0004899541,0.000001890406,0.00004732716,0.00005215388,0.0005614619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004588483,"threshold_uncertainty_score":0.9999415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006049211095765106,"score_gpt":0.2046755701390787,"score_spread":0.1986263590433136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}