{"id":"W2949791399","doi":"10.1186/s12885-019-5805-z","title":"A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; Movember Foundation; Commonwealth Foundation; Astellas Pharma; Astellas Pharma US; National Cancer Institute; National Institutes of Health; Astellas Foundation for Research on Metabolic Disorders; Prostate Cancer Foundation","keywords":"Enzalutamide; Medicine; Prostate cancer; Placebo; Prostatectomy; Androgen deprivation therapy; Urology; Clinical endpoint; Internal medicine; Radiation therapy; Randomized controlled trial; Oncology; Cancer; Androgen receptor; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003829665,0.003824246,0.005717229,0.001111722,0.0009727547,0.001496613,0.002282525,0.003108284,0.01053277],"category_scores_gemma":[0.002779608,0.001649572,0.002394223,0.0007463216,0.003092788,0.001660608,0.0005687076,0.004075573,0.002059507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000948813,"about_ca_system_score_gemma":0.002937427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038281,"about_ca_topic_score_gemma":0.002195926,"domain_scores_codex":[0.9983574,0.0008577665,0.0001185753,0.0003184601,0.0001277744,0.0002199841],"domain_scores_gemma":[0.9974898,0.0006080393,0.0005775395,0.0002558775,0.0002234577,0.0008452839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9694163,0.02257368,0.0001522218,0.0003695417,0.0003296734,0.00001684911,0.00003464137,0.0001343862,0.002964448,0.00006122257,0.0003086547,0.003638373],"study_design_scores_gemma":[0.9146128,0.08406832,0.0003456848,0.00001132969,0.0001514025,0.000009072885,0.00001076606,0.0001726377,0.0003487282,0.00005232261,0.0002076203,0.000009263787],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558055,0.002947141,0.001886252,0.0007627015,0.001723581,0.0317596,0.001787746,0.0003978679,0.002929579],"genre_scores_gemma":[0.9159268,0.003986471,0.007517039,0.002416329,0.002268811,0.05554757,0.001977344,0.0001047732,0.01025493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01053277,"threshold_uncertainty_score":0.03523564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03173270078123806,"score_gpt":0.3531103047933086,"score_spread":0.3213776040120705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}