{"id":"W2949799705","doi":"10.1002/glia.23572","title":"A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease","year":2019,"lang":"en","type":"review","venue":"Glia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada","keywords":"Microglia; Biology; Transcriptome; Neuroscience; Entorhinal cortex; Human brain; Disease; Context (archaeology); Gene signature; Alzheimer's disease; Gene; Computational biology; Hippocampus; Inflammation; Immunology; Gene expression; Genetics; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001696899,0.0003346439,0.000662199,0.0002682302,0.0001693259,0.00007745876,0.0001963301,0.000177027,0.00003981271],"category_scores_gemma":[0.0001697112,0.0002935488,0.0001356365,0.0003938273,0.00008688548,0.0002429139,0.0000362434,0.000422518,0.000005912641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000488328,"about_ca_system_score_gemma":0.0002196818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004675459,"about_ca_topic_score_gemma":0.00004685343,"domain_scores_codex":[0.9976659,0.0004013362,0.0006500494,0.0006802271,0.0003911173,0.0002113939],"domain_scores_gemma":[0.9988158,0.0001708466,0.0004888917,0.0003298787,0.00008584977,0.0001087065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005715975,0.00280766,0.0007949534,0.01765018,0.0004239709,0.001220151,0.003312026,0.0004244109,0.5759581,0.1403918,0.001726334,0.2547189],"study_design_scores_gemma":[0.03964432,0.005436953,0.01614338,0.1658193,0.02441358,0.001673105,0.0004396597,0.02349272,0.3238286,0.01447721,0.3637821,0.02084905],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06872534,0.9216416,0.001108339,0.0002408198,0.000781895,0.005989964,0.001059283,0.0002522905,0.0002004191],"genre_scores_gemma":[0.3736168,0.6239954,0.0001023663,0.0004580875,0.0000964819,0.0002351144,0.0008178294,0.0001221142,0.0005558414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3620558,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2860772380099769,"score_gpt":0.3363066834817204,"score_spread":0.05022944547174346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}