{"id":"W2949814266","doi":"10.1002/hon.118_2630","title":"CORRELATIVE ANALYSES OF CYTOKINE RELEASE SYNDROME AND NEUROLOGICAL EVENTS IN TISAGENLECLEUCEL‐TREATED RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA PATIENTS","year":2019,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; McMaster University","funders":"","keywords":"Cytokine release syndrome; Medicine; Internal medicine; Refractory (planetary science); Gastroenterology; Clinical endpoint; Lymphoma; Diffuse large B-cell lymphoma; Phases of clinical research; Cytokine; Peripheral T-cell lymphoma; Clinical trial; Immunotherapy; Immunology; T cell; Immune system; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003589329,0.0003107318,0.001426302,0.0003188635,0.00004283723,0.000003738064,0.0001833615,0.0006616547,0.002201002],"category_scores_gemma":[0.0005287587,0.0002235353,0.0001740255,0.0005175185,0.0002544988,0.00007677104,0.0002625464,0.0005756715,0.0001805565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025108,"about_ca_system_score_gemma":0.0001208087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005606926,"about_ca_topic_score_gemma":0.00001387025,"domain_scores_codex":[0.9967701,0.0007265485,0.0007566529,0.000683933,0.000433415,0.0006293522],"domain_scores_gemma":[0.9976528,0.001183451,0.0002864896,0.0004197922,0.0001486353,0.0003088079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004480741,0.01623336,0.9585636,0.000141388,0.00008777887,0.00200012,0.0001280453,0.000002368153,0.01643693,0.0001015501,0.0000900702,0.001734028],"study_design_scores_gemma":[0.03395745,0.01184967,0.9483857,0.00007151147,0.0001009125,0.000594423,0.00006695381,0.0007371784,0.001919213,0.0001809423,0.001902171,0.0002339526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949792,0.0003199308,0.000009088615,0.0001754322,0.00009799022,0.001093956,0.00002366892,0.00005458965,0.00324617],"genre_scores_gemma":[0.9976971,0.0002615998,0.0001153722,0.0004323085,0.00001083058,0.00004585575,0.00007481941,0.0000297466,0.001332389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02947671,"threshold_uncertainty_score":0.9987111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648638014391697,"score_gpt":0.3376116835436119,"score_spread":0.301125303399695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}