{"id":"W2949825836","doi":"10.1002/chin.200118130","title":"ChemInform Abstract: Phthalazine PDE4 Inhibitors. Part 2. The Synthesis and Biological Evaluation of 6‐Methoxy‐1,4‐disubstituted Derivatives.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carbon Engineering (Canada)","funders":"","keywords":"Chemistry; Phthalazine; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219431,0.001693967,0.0005165959,0.0007629948,0.0002091761,0.0002515823,0.0005989427,0.0004380481,0.03710901],"category_scores_gemma":[0.0001794193,0.0004862934,0.0004358077,0.0005408883,0.0002217441,0.0004491975,0.0002193075,0.0009578952,0.01452993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005873828,"about_ca_system_score_gemma":0.0005415481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009433289,"about_ca_topic_score_gemma":0.001432325,"domain_scores_codex":[0.9999076,0.0000142856,0.000005828791,0.00001698411,0.00003500531,0.00002027299],"domain_scores_gemma":[0.9999387,0.000009878511,0.00001507874,0.000006186072,0.000008311721,0.00002185057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004546367,0.0009325216,0.0002562851,0.003226142,0.0001172932,0.0005525397,0.00006313395,0.002540289,0.6434425,0.003047138,0.07647904,0.2647969],"study_design_scores_gemma":[0.001872806,0.004742647,0.00437089,0.0001422612,0.0001920243,0.001414112,0.00001868967,0.0009196039,0.7238008,0.0008620913,0.2615988,0.00006531135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2592229,0.293871,0.03765592,0.005937918,0.005444325,0.002835977,0.06228473,0.005916018,0.3268311],"genre_scores_gemma":[0.3979675,0.1743136,0.01864397,0.002391969,0.001362634,0.000863031,0.04590962,0.0004532608,0.3580944],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03710901,"threshold_uncertainty_score":0.1241421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04056415221740337,"score_gpt":0.2820313319724023,"score_spread":0.241467179754999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}