{"id":"W2949825836","doi":"10.1002/chin.200118130","title":"ChemInform Abstract: Phthalazine PDE4 Inhibitors. Part 2. The Synthesis and Biological Evaluation of 6‐Methoxy‐1,4‐disubstituted Derivatives.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carbon Engineering (Canada)","funders":"","keywords":"Chemistry; Phthalazine; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006394476,0.0001537153,0.0001476373,0.00002890609,0.00009455678,0.00001841338,0.0001037913,0.000182386,0.0003324248],"category_scores_gemma":[0.0005319668,0.0001009595,0.00007077385,0.0001242201,0.0002356246,0.00001697048,0.00007124009,0.00007288738,0.000004951869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002445919,"about_ca_system_score_gemma":0.0000619468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005702726,"about_ca_topic_score_gemma":0.000004315668,"domain_scores_codex":[0.9991091,9.015021e-7,0.0003142813,0.0001889912,0.0002244437,0.0001622442],"domain_scores_gemma":[0.999233,0.00005060754,0.0001915147,0.0002516478,0.0002127203,0.00006049143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002111844,0.00008745922,0.001948189,0.00004043262,0.0001076281,8.161255e-7,0.0002839375,0.000007038817,0.2530589,0.00006692294,0.009389506,0.734798],"study_design_scores_gemma":[0.0004452856,0.00004521917,0.02757116,0.00002845586,0.00004114272,0.00003074791,0.000221874,0.00004723608,0.8979812,0.00004691662,0.07339448,0.0001463442],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8601046,0.0006625982,0.000003452473,0.0001720496,0.0001470523,0.0002685495,0.00001119649,0.00001474215,0.1386158],"genre_scores_gemma":[0.9975601,0.0004478912,0.00002588441,0.0000824991,0.0001818672,0.00006629674,0.0001707227,0.000008055333,0.001456671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7346517,"threshold_uncertainty_score":0.4117009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04056415221740337,"score_gpt":0.2820313319724023,"score_spread":0.241467179754999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}