{"id":"W2949833351","doi":"10.1002/chin.200431104","title":"Sulfonamido, Azidosulfonyl and N‐Acetylsulfonamido Analogues of Rofecoxib: 4‐[4‐(N‐Acetylsulfonamido)phenyl] ‐3‐(4‐methanesulfonylphenyl)‐2(5H)furanone is a Potent and Selective Cyclooxygenase‐2 Inhibitor.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Rofecoxib; Cyclooxygenase; Pharmacology; COX-2 inhibitor; Stereochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464796,0.0002644468,0.0002698103,0.0001855733,0.0001348196,0.000148316,0.0003036839,0.0002256636,0.00268559],"category_scores_gemma":[0.0001207821,0.00008808921,0.0001430782,0.0001243952,0.0002227345,0.0001654367,0.0001064568,0.0003151402,0.0006065461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347532,"about_ca_system_score_gemma":0.0002912353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022467,"about_ca_topic_score_gemma":0.001874151,"domain_scores_codex":[0.999897,0.0000239036,0.000008750209,0.00001345633,0.00002856121,0.00002834962],"domain_scores_gemma":[0.9999416,0.000006545326,0.00001694813,0.000005862673,0.000006720531,0.00002245794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001691899,0.0001760567,0.0003878323,0.0001354863,0.00002708931,0.0002679298,0.00004070738,0.000519123,0.9756035,0.001171568,0.001115115,0.01886361],"study_design_scores_gemma":[0.0007099065,0.005932692,0.006622416,0.00001585726,0.00005883549,0.001562781,0.00005155149,0.001501731,0.9459032,0.0001839141,0.03743345,0.00002362753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747961,0.008241078,0.002147447,0.0003595241,0.0001910238,0.000116981,0.001126835,0.0001449757,0.01287598],"genre_scores_gemma":[0.9888378,0.002716798,0.002077012,0.00007814423,0.00005206883,0.00005991475,0.0007246686,0.000007977069,0.005445586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00268559,"threshold_uncertainty_score":0.008984149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007198382487337457,"score_gpt":0.2286197346022882,"score_spread":0.2214213521149507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}