{"id":"W2949849150","doi":"10.3389/fneur.2019.00486","title":"Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Key Research and Development Program of Ningxia; National Institutes of Health; H. Lundbeck A/S; Servier; U.S. Department of Defense; Eli Lilly and Company; Natural Science Foundation of Ningxia Province; Ningxia Medical University; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; University of Southern California; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Standardized uptake value; Neuroimaging; Positron emission tomography; Statistical parametric mapping; White matter; Binding potential; Psychology; Nuclear medicine; Cognitive impairment; Partial volume; Alzheimer's Disease Neuroimaging Initiative; Tau pathology; Alzheimer's disease; Neuroscience; Magnetic resonance imaging; Medicine; Internal medicine; Cognition; Disease; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005681943,0.0003448972,0.0003654975,0.00098896,0.0002347619,0.0004951412,0.0001556942,0.0004102282,0.0006707761],"category_scores_gemma":[0.001193789,0.0002085303,0.0001986123,0.0003973081,0.0002520276,0.0002923573,0.0002269694,0.0001620194,0.0001494366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765734,"about_ca_system_score_gemma":0.000138829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002727393,"about_ca_topic_score_gemma":0.003842631,"domain_scores_codex":[0.9998206,0.00004040094,0.00002829924,0.00004951594,0.00004089663,0.00002029365],"domain_scores_gemma":[0.9996669,0.0000810396,0.0001041725,0.00002393418,0.00004271012,0.00008131946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003841092,0.0001786876,0.9694605,0.00007181012,0.0001503814,0.0007234091,0.0007603676,0.0002022339,0.01421087,0.00006138427,0.0001005771,0.01023879],"study_design_scores_gemma":[0.00003149588,0.0005314414,0.9974259,0.000004708767,0.00004257911,0.0007180239,0.0001695164,0.0002617434,0.000663928,0.00003452643,0.0001116014,0.000004457338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992157,0.0003540809,0.00007327295,0.000005230329,0.000001406111,0.000007147949,0.00006962821,0.000003671898,0.0002697385],"genre_scores_gemma":[0.9994776,0.0001051757,0.0001435884,0.00001402679,0.000004034448,0.00001079854,0.0001083996,0.000001573141,0.0001348469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002727393,"threshold_uncertainty_score":0.005423009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008072557675127141,"score_gpt":0.2776026218700245,"score_spread":0.2695300641948974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}