{"id":"W2949932581","doi":"10.1038/s41594-019-0246-6","title":"Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition","year":2019,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; U.S. National Library of Medicine; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; Ontario Genomics; National Institutes of Health; National Center for Research Resources; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; University of Chicago; Pfizer; Argonne National Laboratory; U.S. Department of Energy","keywords":"AP site; DNA; DNA clamp; Biology; HMG-box; Duplex (building); DNA replication; Replication protein A; DNA ligase; DNA damage; DNA repair; Base pair; Chemistry; Biochemistry; Biophysics; DNA-binding protein; Reverse transcriptase; RNA; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019811,0.0002512816,0.0002407193,0.0001344653,0.0004368679,0.0004668024,0.0005177712,0.0003959925,0.006267321],"category_scores_gemma":[0.0003206533,0.0002083943,0.000218524,0.000134151,0.0003039403,0.0002968555,0.000329418,0.0007029913,0.001088502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006356479,"about_ca_system_score_gemma":0.0002713509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213978,"about_ca_topic_score_gemma":0.001233641,"domain_scores_codex":[0.9998697,0.00001622889,0.000006539378,0.00002778423,0.00003585169,0.0000438261],"domain_scores_gemma":[0.9997666,0.00007097808,0.00003701652,0.00002623601,0.00003211809,0.00006698429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004582739,0.00006480952,0.001898963,0.00007158123,0.00002015642,0.0005808023,0.00006739573,0.00200446,0.9833744,0.00661579,0.0003574994,0.004485948],"study_design_scores_gemma":[0.00003315855,0.0001190156,0.006875577,0.000009702323,0.00001161126,0.0004353892,0.0001118958,0.01074522,0.97655,0.001037389,0.004055917,0.00001501738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903678,0.0005113623,0.004326119,0.0001944458,0.00004851212,0.00001331253,0.0001101512,0.00009701383,0.004331248],"genre_scores_gemma":[0.9972658,0.00008981414,0.0008301212,0.00004558192,0.000006147313,0.00000434188,0.0001436995,0.000009242461,0.001605328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006267321,"threshold_uncertainty_score":0.02096623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005245630150452825,"score_gpt":0.264655769057158,"score_spread":0.2594101389067052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}