{"id":"W2949933084","doi":"10.1101/663385","title":"PARP1 as a biomarker for early detection and intraoperative tumor delineation in epithelial cancers – first-in-human results","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Missouri Soybean Merchandising Council; McGill University; National Institutes of Health; Tow Foundation; Memorial Sloan-Kettering Cancer Center","keywords":"Medicine; Biomarker; Cancer; Esophageal cancer; Biopsy; Pathology; Clinical significance; Oncology; Cancer research; Radiology; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006204854,0.001574953,0.0009241209,0.0005244721,0.0004179974,0.001372649,0.0007819482,0.00141321,0.003886298],"category_scores_gemma":[0.001901425,0.0005370982,0.001085507,0.0003547452,0.0008545695,0.0009188123,0.0006169722,0.002201306,0.001224453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008116037,"about_ca_system_score_gemma":0.0007660398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007613334,"about_ca_topic_score_gemma":0.0008588453,"domain_scores_codex":[0.997621,0.001318833,0.0001017114,0.0003184201,0.0004066434,0.0002334081],"domain_scores_gemma":[0.9984496,0.000358967,0.0002478994,0.0003162368,0.0004271337,0.000200089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005487419,0.004407352,0.008229055,0.001547845,0.0005830971,0.0004551063,0.0003301259,0.002504399,0.9015576,0.0008942694,0.007307524,0.06669624],"study_design_scores_gemma":[0.0002142105,0.01520656,0.00591289,0.00007904247,0.0004372529,0.001580751,0.0001706238,0.00391377,0.9502717,0.0004118841,0.02174005,0.00006124318],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7892511,0.04793144,0.1354517,0.003531355,0.001007496,0.00308359,0.005696897,0.001886891,0.01215946],"genre_scores_gemma":[0.9202031,0.01232049,0.04906563,0.001694757,0.0002138475,0.001144037,0.005462134,0.000340819,0.009555084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006204854,"threshold_uncertainty_score":0.0328148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006939597251315,"score_gpt":0.2735091021033549,"score_spread":0.2534397061308418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}