{"id":"W2949973349","doi":"10.1097/01.hs9.0000562776.32990.9f","title":"PS1123 IMPACT OF MAJOR GENOMIC ALTERATIONS ON OUTCOME OF RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED WITH VENETOCLAX PLUS RITUXIMAB IN THE PHASE 3 MURANO STUDY","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"IGHV@; Venetoclax; Rituximab; Chronic lymphocytic leukemia; Chemoimmunotherapy; Neuroblastoma RAS viral oncogene homolog; Bendamustine; Oncology; KRAS; Internal medicine; Medicine; Lenalidomide; Somatic evolution in cancer; CDKN2A; Lymphocytosis; Leukemia; Lymphoma; Multiple myeloma; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009750532,0.00020712,0.0004646486,0.0001264724,0.0001488382,0.0003798726,0.0002077082,0.0002055608,0.001080386],"category_scores_gemma":[0.0007377568,0.00008688804,0.0004027729,0.0001952429,0.0001556543,0.0001857572,0.0002322353,0.0003498049,0.0001181784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820145,"about_ca_system_score_gemma":0.0003190344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006411921,"about_ca_topic_score_gemma":0.001981612,"domain_scores_codex":[0.9997244,0.0001465228,0.00001544341,0.0000492078,0.00003408664,0.00003022825],"domain_scores_gemma":[0.9995958,0.0001143064,0.0001656878,0.00003185562,0.00002167289,0.0000707025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1542558,0.001430966,0.7228643,0.0003727171,0.002322403,0.000353453,0.0002843894,0.001919431,0.02615521,0.0001426168,0.002352719,0.08754596],"study_design_scores_gemma":[0.00852385,0.02244061,0.9623364,0.00003293149,0.0009130034,0.0004359875,0.000051784,0.001138897,0.00146907,0.0001104169,0.002533289,0.00001393458],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986927,0.0005807272,0.00003629007,0.00004274914,0.000005158594,0.00002550278,0.0002150623,0.0000041037,0.0003977226],"genre_scores_gemma":[0.999091,0.0001205462,0.00005258757,0.0000480313,0.00001279263,0.0000262629,0.0005154926,0.000001931406,0.0001313534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080386,"threshold_uncertainty_score":0.005156636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167245289051603,"score_gpt":0.3328239488528844,"score_spread":0.3111514959623684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}