{"id":"W2949973349","doi":"10.1097/01.hs9.0000562776.32990.9f","title":"PS1123 IMPACT OF MAJOR GENOMIC ALTERATIONS ON OUTCOME OF RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED WITH VENETOCLAX PLUS RITUXIMAB IN THE PHASE 3 MURANO STUDY","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"IGHV@; Venetoclax; Rituximab; Chronic lymphocytic leukemia; Chemoimmunotherapy; Neuroblastoma RAS viral oncogene homolog; Bendamustine; Oncology; KRAS; Internal medicine; Medicine; Lenalidomide; Somatic evolution in cancer; CDKN2A; Lymphocytosis; Leukemia; Lymphoma; Multiple myeloma; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003526085,0.0003524105,0.0008930404,0.0001855957,0.00005597279,0.00001862571,0.0003496106,0.0001420408,0.0007069795],"category_scores_gemma":[0.00008927688,0.0002137629,0.0002132349,0.0005846476,0.0001422179,0.0001167517,0.00006440368,0.0003728695,0.0001781434],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1331327,"about_ca_system_score_gemma":0.02802502,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008367278,"about_ca_topic_score_gemma":0.0006006289,"domain_scores_codex":[0.9972112,0.0002146546,0.000806726,0.0004743208,0.0007811989,0.0005118716],"domain_scores_gemma":[0.9977924,0.0003378426,0.0003092067,0.001240744,0.000187203,0.0001325775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03815796,0.01383896,0.8396955,0.003510362,0.002813572,0.001005127,0.0136263,0.06389342,0.01747483,0.0001480312,0.001643466,0.004192514],"study_design_scores_gemma":[0.6507887,0.04760444,0.2253538,0.001153972,0.0006015996,0.0001450926,0.001880569,0.06864335,0.003006419,0.0000115516,0.0001610784,0.0006494346],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946154,0.0002895394,0.000004268445,0.000007723931,0.00004830639,0.003430878,0.00005234385,0.00002822986,0.001523333],"genre_scores_gemma":[0.9988671,0.00001652007,0.0000287361,0.00003878234,0.00005339864,0.000114622,0.00009272172,0.0000672647,0.0007208432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6143417,"threshold_uncertainty_score":0.9982361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167245289051603,"score_gpt":0.3328239488528844,"score_spread":0.3111514959623684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}