{"id":"W2949979810","doi":"10.1101/621102","title":"Dual delivery of nucleic acids and PEGylated-bisphosphonates <i>via</i> calcium phosphate nanoparticles","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transfection; Gene delivery; Chemistry; Internalization; Nucleic acid; In vivo; Conjugate; Calcium; Biophysics; Biochemistry; Cell; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611647,0.000481991,0.000222119,0.0001900398,0.00009879078,0.0003040165,0.0002433579,0.0003858448,0.002641726],"category_scores_gemma":[0.0001234467,0.0001586034,0.000269208,0.0001420388,0.000168861,0.0003237166,0.0002195551,0.0004266007,0.0008369053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836349,"about_ca_system_score_gemma":0.0001759339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003947263,"about_ca_topic_score_gemma":0.000366938,"domain_scores_codex":[0.9998807,0.00001191955,0.000005159414,0.00003975612,0.00003687803,0.00002564729],"domain_scores_gemma":[0.9999675,0.000006165183,0.00001256127,0.000002860295,0.000005116818,0.000005817189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152674,0.00001472104,0.00004543253,0.0001861929,0.000009293623,0.00005447231,0.00001521432,0.0004108793,0.9941252,0.0007655893,0.0003192338,0.003938407],"study_design_scores_gemma":[0.00001150755,0.00005439017,0.0001120647,0.000005417035,0.000006265882,0.00003108501,0.000003106087,0.0009345379,0.9954104,0.00007435666,0.003352182,0.000004754731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9097178,0.009006145,0.05696392,0.0008596965,0.0003739672,0.000201675,0.001164171,0.001160756,0.02055191],"genre_scores_gemma":[0.9672463,0.002251487,0.01749687,0.0001731959,0.00003680152,0.00008076619,0.0004181435,0.00008420539,0.01221228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002641726,"threshold_uncertainty_score":0.008837521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00963339424849909,"score_gpt":0.2090869774491907,"score_spread":0.1994535832006916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}