{"id":"W2949982249","doi":"10.1021/ol006146k","title":"Asymmetric Wolff Rearrangement Reactions with α-Alkylated-α-diazoketones:  Stereoselective Synthesis of α-Substituted-β-amino Acid Derivatives","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Stereoselectivity; Steric effects; Alkylation; Alpha (finance); Stereochemistry; Wolff rearrangement; Amino acid; Rearrangement reaction; Medicinal chemistry; Organic chemistry; Catalysis; Diazo; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045927,0.0005966054,0.000425418,0.0002921291,0.0002366569,0.0001895503,0.0003471528,0.0003877952,0.001495481],"category_scores_gemma":[0.000324093,0.0002164685,0.0002662909,0.0002039634,0.0002085197,0.0004906813,0.000233185,0.0005457298,0.0005932935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352143,"about_ca_system_score_gemma":0.0002259564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002907158,"about_ca_topic_score_gemma":0.0005695864,"domain_scores_codex":[0.9998322,0.00003365612,0.00001502383,0.00002495162,0.00003270801,0.00006157636],"domain_scores_gemma":[0.9998995,0.00001963722,0.0000285712,0.00001184243,0.00001593801,0.00002438102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001311469,0.00003509741,0.000114969,0.0001294122,0.00001577064,0.0005147808,0.0000831678,0.0003717982,0.986874,0.001400754,0.0001686776,0.01016031],"study_design_scores_gemma":[0.00002606676,0.0001527953,0.0003272629,0.000004794907,0.000008178665,0.0004011735,0.0000180901,0.0003917684,0.9961157,0.000189685,0.002353459,0.00001094553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552412,0.00451445,0.02361342,0.0003319352,0.000193439,0.0001541055,0.0001960095,0.000180316,0.01557515],"genre_scores_gemma":[0.9849063,0.00239756,0.007036609,0.00009209201,0.00002220929,0.00005957281,0.0001096525,0.00004169297,0.005334443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495481,"threshold_uncertainty_score":0.005002856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008177099295663208,"score_gpt":0.2022981654590932,"score_spread":0.1941210661634299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}