{"id":"W2949982249","doi":"10.1021/ol006146k","title":"Asymmetric Wolff Rearrangement Reactions with α-Alkylated-α-diazoketones:  Stereoselective Synthesis of α-Substituted-β-amino Acid Derivatives","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Stereoselectivity; Steric effects; Alkylation; Alpha (finance); Stereochemistry; Wolff rearrangement; Amino acid; Rearrangement reaction; Medicinal chemistry; Organic chemistry; Catalysis; Diazo; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009841524,0.0003439444,0.0003914166,0.0002589262,0.0001611158,0.0000396578,0.0002857494,0.0001400185,0.005345446],"category_scores_gemma":[0.00009516469,0.000313461,0.000103574,0.001060412,0.0001290236,0.0002686784,0.00003103775,0.000331833,0.000214047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004372547,"about_ca_system_score_gemma":0.00009557905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001575291,"about_ca_topic_score_gemma":0.00003081968,"domain_scores_codex":[0.9981096,0.00005009154,0.0004289882,0.0005336933,0.000466743,0.0004109156],"domain_scores_gemma":[0.9987413,0.0001715038,0.0002614159,0.0005904164,0.0001124675,0.0001229058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200143,0.0001361589,0.0004726351,0.0001324261,0.0002876135,0.00002696385,0.0006996001,0.00002098252,0.9689381,0.00002193738,0.0001667123,0.02897682],"study_design_scores_gemma":[0.0005860024,0.00004272762,0.001614642,0.0001510375,0.0001656973,0.00008268913,0.0008905334,0.00001104876,0.9929982,0.00000897044,0.003087072,0.0003613166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878926,0.0001433513,0.0008836678,0.0005157969,0.00006702067,0.0001966837,0.00002455764,0.0002591472,0.01001712],"genre_scores_gemma":[0.9974056,0.0001678902,0.001628429,0.0001602843,0.000105587,0.0000702612,0.00002426333,0.00008631219,0.0003513343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0286155,"threshold_uncertainty_score":0.9999318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008177099295663208,"score_gpt":0.2022981654590932,"score_spread":0.1941210661634299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}