{"id":"W2950012657","doi":"10.1002/chin.200530131","title":"Design and Synthesis of a Potent Macrocyclic 1,6‐Naphthyridine anti‐Human Cytomegalovirus (HCMV) Inhibitors.","year":2005,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Combinatorial chemistry; Cytomegalovirus; Stereochemistry; Virology; Biochemistry; Virus; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001616332,0.0005123883,0.000368349,0.0002201804,0.0001871616,0.0002981852,0.0004707066,0.0002684521,0.002486892],"category_scores_gemma":[0.0001229395,0.0002159362,0.0002114867,0.0001515792,0.0001355061,0.0002063928,0.0001982328,0.0004386538,0.0009595361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117937,"about_ca_system_score_gemma":0.0003752702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006234002,"about_ca_topic_score_gemma":0.002160243,"domain_scores_codex":[0.9999264,0.00001289841,0.000006541383,0.00001442643,0.00001822292,0.00002144804],"domain_scores_gemma":[0.9999629,0.000003345151,0.00001015304,0.000003528018,0.000006512583,0.00001354421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004284656,0.0002177093,0.0001390038,0.0004270723,0.00004025309,0.0004102133,0.00008955212,0.002900703,0.9550848,0.001781574,0.001552576,0.03692808],"study_design_scores_gemma":[0.0004117408,0.004195655,0.001236714,0.00005455762,0.00009737781,0.0009081718,0.00003304813,0.00271321,0.9167398,0.0003572519,0.07321176,0.00004068379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8398737,0.03465168,0.0748906,0.00106151,0.0005903818,0.002604102,0.004458472,0.0009677724,0.04090175],"genre_scores_gemma":[0.9114082,0.02153337,0.04292848,0.0003918436,0.00009462252,0.000662658,0.003666418,0.00008910759,0.01922517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002486892,"threshold_uncertainty_score":0.008319438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02739342266823117,"score_gpt":0.2583254323005834,"score_spread":0.2309320096323522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}