{"id":"W2950012657","doi":"10.1002/chin.200530131","title":"Design and Synthesis of a Potent Macrocyclic 1,6‐Naphthyridine anti‐Human Cytomegalovirus (HCMV) Inhibitors.","year":2005,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Combinatorial chemistry; Cytomegalovirus; Stereochemistry; Virology; Biochemistry; Virus; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003298742,0.0001932962,0.0003138045,0.00005094968,0.00008200029,0.00002697738,0.0001579914,0.0001954934,0.0006397225],"category_scores_gemma":[0.0001952706,0.0001464209,0.00009400243,0.00008720451,0.0001255393,0.0001242368,0.00007589895,0.0001005709,0.00003365963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007244126,"about_ca_system_score_gemma":0.0000215437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001159599,"about_ca_topic_score_gemma":0.00000104076,"domain_scores_codex":[0.9988475,0.000001572815,0.0004426208,0.0002324601,0.0002295349,0.0002462846],"domain_scores_gemma":[0.9991792,0.0002291482,0.0002040912,0.0002302347,0.00005860413,0.00009872048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000353402,0.00009742309,0.0002221513,0.0000743327,0.00003063079,0.000001269311,0.00007334038,0.000003320551,0.5877291,0.00003198444,0.000926434,0.4107746],"study_design_scores_gemma":[0.0003469223,0.00002484612,0.0004806285,0.00008405752,0.00004006736,0.00001896877,0.00007084926,0.0002254229,0.99402,0.0000621759,0.004431065,0.0001949606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8667989,0.0003417673,0.00001131926,0.0002565044,0.00001728776,0.0001192853,0.00001321171,0.00007688236,0.1323648],"genre_scores_gemma":[0.9983902,0.0001362016,0.0004871711,0.00005498997,0.0001598164,0.00003587364,0.00001307495,0.00001375173,0.0007089344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4105797,"threshold_uncertainty_score":0.7004513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02739342266823117,"score_gpt":0.2583254323005834,"score_spread":0.2309320096323522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}