{"id":"W2950014740","doi":"10.1089/ars.2019.7728","title":"S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury","year":2019,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"SIRT3; Acute kidney injury; Nephrotoxicity; Mitochondrion; Oxidative stress; Superoxide dismutase; Medicine; Pharmacology; Chemistry; Kidney; Biochemistry; Internal medicine; Enzyme; Sirtuin; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302806,0.0002089896,0.0004284741,0.0002167729,0.00005831754,0.00002589167,0.00006214907,0.0002300597,0.0001163022],"category_scores_gemma":[0.00009102095,0.0001933445,0.00008142168,0.0003408812,0.000044348,0.0002587092,0.0000257535,0.0002299171,0.00001915846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006208925,"about_ca_system_score_gemma":0.0001005134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001313685,"about_ca_topic_score_gemma":0.000004058063,"domain_scores_codex":[0.9984311,0.00005783789,0.0005465445,0.0003953083,0.0003192117,0.0002499956],"domain_scores_gemma":[0.9992405,0.00005264298,0.0002576649,0.0002219013,0.00009555998,0.0001316986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003662562,0.00009853938,0.01448127,0.00008550695,0.00009410616,0.000005306577,0.0003849354,0.000006168898,0.9819835,0.00002257084,0.0003129941,0.00215884],"study_design_scores_gemma":[0.003068754,0.0003893934,0.003754228,0.0004246273,0.00008771425,0.00002305834,0.0001177034,0.001168304,0.9905329,0.0001245724,0.0001104423,0.0001983071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980332,0.00007616969,0.0001578928,0.0005939659,0.0002581716,0.000615743,0.00003791756,0.00004203543,0.0001849436],"genre_scores_gemma":[0.9985269,0.00009705317,0.0003471314,0.0003630301,0.0001676866,0.0000063445,0.0001446512,0.00003988582,0.0003072961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01072705,"threshold_uncertainty_score":0.7884361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00691181033101528,"score_gpt":0.2441333087882237,"score_spread":0.2372214984572084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}