{"id":"W2950014740","doi":"10.1089/ars.2019.7728","title":"S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury","year":2019,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"SIRT3; Acute kidney injury; Nephrotoxicity; Mitochondrion; Oxidative stress; Superoxide dismutase; Medicine; Pharmacology; Chemistry; Kidney; Biochemistry; Internal medicine; Enzyme; Sirtuin; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003844,0.0004872088,0.0005307035,0.0002098299,0.0001924063,0.0001809201,0.000267834,0.0002912054,0.001318658],"category_scores_gemma":[0.0001260636,0.0001201548,0.0004578913,0.0001511582,0.0003953706,0.0002522822,0.0002601272,0.0005551621,0.0001668961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243689,"about_ca_system_score_gemma":0.0003171869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005070756,"about_ca_topic_score_gemma":0.001106921,"domain_scores_codex":[0.9998927,0.00002172672,0.00001291599,0.00001764944,0.00002561274,0.00002945078],"domain_scores_gemma":[0.9999325,0.00000402546,0.00002321003,0.00000713605,0.00001081656,0.0000222224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180282,0.0001999441,0.000445168,0.0001552806,0.00004099975,0.00005077768,0.00002199228,0.0001727501,0.9923319,0.00008846635,0.0001849939,0.005127428],"study_design_scores_gemma":[0.0002057227,0.002519324,0.007405511,0.00001334878,0.00009029505,0.0001562252,0.00003612203,0.001501229,0.9856178,0.0001001749,0.002343945,0.00001029839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900258,0.0038994,0.004376978,0.0003040224,0.0001580416,0.00006484349,0.000177307,0.0002085196,0.0007851441],"genre_scores_gemma":[0.996251,0.001390723,0.001250589,0.00008266806,0.0000241451,0.00003764707,0.000174494,0.00001079872,0.0007779574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318658,"threshold_uncertainty_score":0.00441134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00691181033101528,"score_gpt":0.2441333087882237,"score_spread":0.2372214984572084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}