{"id":"W2950035458","doi":"10.21037/atm.2019.05.51","title":"Looking beyond cancer for cabozantinib-induced cardiotoxicity: evidence of absence or absence of evidence?","year":2019,"lang":"en","type":"letter","venue":"Annals of Translational Medicine","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Pazopanib; Cardiotoxicity; Sunitinib; Medicine; Bevacizumab; Axitinib; Cabozantinib; Oncology; Internal medicine; Intensive care medicine; Cancer; Disease; Targeted therapy; Heart failure; Vascular endothelial growth factor; Tyrosine-kinase inhibitor; Tyrosine kinase; VEGF receptors; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00256897,0.0003435531,0.0009069298,0.0008816037,0.001339328,0.002065344,0.001106158,0.01308278,0.004623875],"category_scores_gemma":[0.019732,0.00026299,0.0006630929,0.0006639337,0.002015427,0.00385029,0.0006999656,0.01323259,0.004290418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002726771,"about_ca_system_score_gemma":0.002196317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142787,"about_ca_topic_score_gemma":0.002468187,"domain_scores_codex":[0.9985511,0.0004987472,0.0003004099,0.0001612369,0.0003714867,0.0001169594],"domain_scores_gemma":[0.9901383,0.005350852,0.0009370645,0.0002790309,0.002298896,0.000995847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002125775,0.0001007005,0.006352359,0.0008634771,0.00007111652,0.0263492,0.0003475326,0.0001280649,0.00112679,0.006750141,0.8443727,0.1133253],"study_design_scores_gemma":[0.0001869676,0.0002002516,0.004254189,0.00333198,0.0001337976,0.05969847,0.001052237,0.0006236197,0.0007438368,0.03667922,0.8930168,0.00007864492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001519102,0.01323125,0.0002396092,0.9673004,0.01348906,0.00001477656,0.00003169845,0.00002288174,0.004151233],"genre_scores_gemma":[0.02727067,0.02180815,0.000871725,0.8106838,0.1347284,0.00002274845,0.000052719,0.00002576865,0.00453592],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01308278,"threshold_uncertainty_score":0.01978427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3099026998954085,"score_gpt":0.4359295233190021,"score_spread":0.1260268234235936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}