{"id":"W2950038861","doi":"10.3390/cells8060597","title":"Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"H2020 Marie Skłodowska-Curie Actions; European Research Council; Associazione Italiana per la Ricerca sul Cancro; AFM-Téléthon; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondation Leducq; Fondazione Cassa di Risparmio di Padova e Rovigo","keywords":"Mitophagy; Mitochondrial fission; MFN2; Skeletal muscle; mitochondrial fusion; Sarcopenia; Biology; Muscle atrophy; Mitochondrion; Autophagy; Cell biology; Endocrinology; Internal medicine; Medicine; Apoptosis; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460406,0.0006216209,0.000526464,0.0004464556,0.0002444532,0.0003694057,0.0003680063,0.000411798,0.001095018],"category_scores_gemma":[0.0001304219,0.0002152575,0.0003348221,0.0001665335,0.000432852,0.0003880195,0.0004028689,0.00110784,0.0002786886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830164,"about_ca_system_score_gemma":0.000423151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005629892,"about_ca_topic_score_gemma":0.00105771,"domain_scores_codex":[0.9997732,0.00002404956,0.00003358645,0.00005502647,0.00006085829,0.0000531911],"domain_scores_gemma":[0.9997438,0.00001756958,0.0001012044,0.00002260038,0.00002516335,0.00008968321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512632,0.00006379625,0.0001185669,0.00006262643,0.00001023049,0.00003485127,0.00001806574,0.00007586808,0.9976992,0.00009322167,0.00003621026,0.00153609],"study_design_scores_gemma":[0.00003768434,0.00103711,0.003591341,0.00001754436,0.00003458439,0.0001888284,0.00005021644,0.0006533448,0.9922161,0.00009087023,0.002075952,0.000006527251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933689,0.001942998,0.003045523,0.0001608683,0.00003984888,0.00003408241,0.000467755,0.0001497218,0.0007903725],"genre_scores_gemma":[0.9923716,0.001528731,0.002274523,0.00006771684,0.0000130631,0.00007484286,0.0005618792,0.00003681448,0.003070928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095018,"threshold_uncertainty_score":0.003663242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003771257109285864,"score_gpt":0.2041663802782955,"score_spread":0.2003951231690097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}