{"id":"W2950038861","doi":"10.3390/cells8060597","title":"Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"H2020 Marie Skłodowska-Curie Actions; European Research Council; Associazione Italiana per la Ricerca sul Cancro; AFM-Téléthon; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondation Leducq; Fondazione Cassa di Risparmio di Padova e Rovigo","keywords":"Mitophagy; Mitochondrial fission; MFN2; Skeletal muscle; mitochondrial fusion; Sarcopenia; Biology; Muscle atrophy; Mitochondrion; Autophagy; Cell biology; Endocrinology; Internal medicine; Medicine; Apoptosis; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006243489,0.00006520882,0.0000742629,0.00002100427,0.00001493101,0.000003175983,0.00005964663,0.0000907532,0.0001227876],"category_scores_gemma":[0.00001604433,0.00004538609,0.0000663458,0.00004593324,0.00003054271,0.000001569712,0.00005709628,0.00005777041,0.00002966938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005427577,"about_ca_system_score_gemma":0.00001932937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001537446,"about_ca_topic_score_gemma":0.00001921231,"domain_scores_codex":[0.9995118,0.0000640837,0.0001311146,0.000145907,0.00005580258,0.00009124532],"domain_scores_gemma":[0.999713,0.000006857256,0.00005207651,0.0001817014,0.00002530793,0.00002103528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002867252,0.00004100142,0.004603578,0.00001893759,0.000002619426,6.558399e-7,0.00003782626,0.00007333238,0.9936799,0.00003820607,0.001190811,0.0002844987],"study_design_scores_gemma":[0.0004858231,0.0001498692,0.006120412,0.00002806137,0.000002993923,0.000003542704,0.00004888795,0.00004542391,0.9880646,0.00004882933,0.00493842,0.0000631541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976821,0.0000593371,0.00002885067,0.0001070798,0.0005568851,0.0001736378,0.00001132809,0.000002898761,0.001377899],"genre_scores_gemma":[0.9981468,0.00004232327,0.00008669117,0.0002858535,0.00007824175,0.000005394914,0.00004189912,0.000006277367,0.001306458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005615279,"threshold_uncertainty_score":0.1850791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003771257109285864,"score_gpt":0.2041663802782955,"score_spread":0.2003951231690097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}