{"id":"W2950057276","doi":"10.1080/19420862.2019.1624126","title":"Rapid single B cell antibody discovery using nanopens and structured light","year":2019,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Amgen (Canada)","funders":"Scheme for Promotion of Academic and Research Collaboration; Amgen","keywords":"Antibody; Monoclonal antibody; Drug discovery; Immunoglobulin light chain; Antigen; Molecular biology; Phage display; B cell; Immunoassay; Chemistry; Recombinant DNA; Immunization; Computational biology; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008064076,0.0001319927,0.0002471058,0.00007968275,0.00007386716,0.00006055916,0.00006755286,0.00006779792,0.0005812441],"category_scores_gemma":[0.00001296494,0.00009466433,0.00006304459,0.0001082631,0.00005462728,0.0001315675,0.0001162032,0.0001575589,0.0001028259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002708848,"about_ca_system_score_gemma":0.00005148831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009839435,"about_ca_topic_score_gemma":0.000005351528,"domain_scores_codex":[0.9990237,0.00002816847,0.0001474378,0.0002515555,0.000267298,0.0002818743],"domain_scores_gemma":[0.99955,0.00003845526,0.00003746264,0.0002052803,0.00004696162,0.0001217839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002325863,0.00006297135,0.03638722,0.0002107861,0.00002619411,0.0000536676,0.0001116019,0.000001465195,0.9609662,0.0001620186,0.0004331424,0.00135218],"study_design_scores_gemma":[0.003585774,0.001369842,0.1438448,0.0003730319,0.0001128334,0.0004513899,0.0003516322,0.001208326,0.6031251,0.0003667465,0.2446206,0.0005900122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843394,0.001696637,0.00001571419,0.0009008909,0.0002066097,0.0002685649,0.00001699156,0.00001847209,0.01253677],"genre_scores_gemma":[0.9803362,0.0001490008,0.0005027458,0.0003142618,0.0001666039,9.325943e-7,0.00003795111,0.00001978801,0.01847246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3578411,"threshold_uncertainty_score":0.6364216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235002650979136,"score_gpt":0.2935686493296544,"score_spread":0.2700683842317408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}