{"id":"W2950057276","doi":"10.1080/19420862.2019.1624126","title":"Rapid single B cell antibody discovery using nanopens and structured light","year":2019,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Amgen (Canada)","funders":"Scheme for Promotion of Academic and Research Collaboration; Amgen","keywords":"Antibody; Monoclonal antibody; Drug discovery; Immunoglobulin light chain; Antigen; Molecular biology; Phage display; B cell; Immunoassay; Chemistry; Recombinant DNA; Immunization; Computational biology; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208509,0.0002967907,0.0001785988,0.0002501102,0.0001515479,0.0003041241,0.0003343554,0.0004139736,0.0005269136],"category_scores_gemma":[0.0002024257,0.0002059422,0.0002355999,0.0001120353,0.0002551027,0.0003262485,0.0004292541,0.0004030089,0.0003312142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900082,"about_ca_system_score_gemma":0.0002423007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932434,"about_ca_topic_score_gemma":0.0008114034,"domain_scores_codex":[0.999811,0.00002213692,0.000008703966,0.00005424774,0.00008396247,0.0000200444],"domain_scores_gemma":[0.999876,0.00004569635,0.00002866037,0.00001671295,0.00002257295,0.000010386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002058208,0.00001239896,0.0001347863,0.00003387872,0.000003447558,0.00002461507,0.000012223,0.0002047604,0.995044,0.000263698,0.00005938132,0.004186212],"study_design_scores_gemma":[0.00000738659,0.00009101468,0.0003720018,0.000003872237,0.000003766241,0.00008334631,0.00001095187,0.005091111,0.99263,0.0001340274,0.001566931,0.000005692541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6945841,0.002288216,0.2969697,0.0003419941,0.00008204338,0.0002254202,0.000477562,0.0009513777,0.00407957],"genre_scores_gemma":[0.7297567,0.001445734,0.2643004,0.0003175108,0.00003707315,0.0002150814,0.0004105376,0.00006343088,0.003453613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005269136,"threshold_uncertainty_score":0.002104163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235002650979136,"score_gpt":0.2935686493296544,"score_spread":0.2700683842317408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}