{"id":"W2950081290","doi":"10.1016/j.nbd.2019.04.004","title":"Heritability and genetic variance of dementia with Lewy bodies","year":2019,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Canada Research Chairs; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute on Drug Abuse; Fogarty International Center; National Heart, Lung, and Blood Institute; Medical Research Council; National Center for Advancing Translational Sciences; National Human Genome Research Institute; NIHR Oxford Biomedical Research Centre; Alzheimer's Society; Wellcome Trust; Agence Nationale de la Recherche; Parkinson's UK; National Institutes of Health; National Institute on Aging; Parkinson's Disease Foundation; BRACE; Michael J. Fox Foundation for Parkinson's Research; Alzheimer's Research Trust; Rosetrees Trust","keywords":"Heritability; Genome-wide association study; Dementia with Lewy bodies; Biology; Linkage disequilibrium; Genetic correlation; Genetic variation; Genetics; Single-nucleotide polymorphism; Genetic association; Genetic architecture; SNP; Disease; Parkinson's disease; Allele; Missing heritability problem; Dementia; Phenotype; Evolutionary biology; Genotype; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002650048,0.0007143656,0.0006622015,0.002631982,0.0007571736,0.0008800921,0.0006236988,0.00100453,0.002412905],"category_scores_gemma":[0.006715027,0.0007101166,0.0008641449,0.001453323,0.001023258,0.0006687565,0.0009469151,0.0008473753,0.000244125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303241,"about_ca_system_score_gemma":0.0003900316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009580619,"about_ca_topic_score_gemma":0.004265578,"domain_scores_codex":[0.9971057,0.001359331,0.0002608419,0.0005880693,0.0004176425,0.0002684601],"domain_scores_gemma":[0.997121,0.001401334,0.0005867288,0.0004801605,0.0002430837,0.0001676145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007957135,0.000151789,0.9833021,0.00002675604,0.0008065193,0.001750615,0.0007694639,0.0009105824,0.004975394,0.001213267,0.0001944742,0.005103376],"study_design_scores_gemma":[0.00002241573,0.00007497126,0.9947191,0.00001371135,0.0002130627,0.001648244,0.0002567099,0.001622654,0.000318382,0.0009708006,0.0001239632,0.00001588763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971624,0.0005561862,0.001145695,0.0001035422,0.00001682085,0.00001000137,0.0001820692,0.00002721746,0.0007959701],"genre_scores_gemma":[0.9993068,0.000125313,0.000264712,0.000007951526,0.00002082852,0.000004460193,0.00008521689,0.00000701107,0.0001776859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009580619,"threshold_uncertainty_score":0.0190497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005224454695302044,"score_gpt":0.2144632901180976,"score_spread":0.2092388354227955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}