{"id":"W2950083834","doi":"10.1136/annrheumdis-2019-eular.1719","title":"OP0068 ABATACEPT IN EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS— RESULTS OF A PHASE 2 INVESTIGATOR-INITIATED, MULTICENTER, DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto","funders":"National Institutes of Health; CSL Behring; Genentech; Acceleron; United Therapeutics Corporation; Sanofi; National Institute of Allergy and Infectious Diseases; Amgen; Pfizer; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Medicine; Double blind; Abatacept; Placebo; Randomized controlled trial; Scleroderma (fungus); Internal medicine; Multicenter study; Systemic scleroderma; Pathology; Alternative medicine; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001070463,0.0004761569,0.003109189,0.0003688723,0.00006187354,0.00004505149,0.0006210847,0.0001499846,0.0001187095],"category_scores_gemma":[0.009166864,0.0003113585,0.001271849,0.000419064,0.0005192747,0.0001898842,0.0001933212,0.0002204051,0.00005784861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005044183,"about_ca_system_score_gemma":0.0006852841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005848443,"about_ca_topic_score_gemma":0.000006109815,"domain_scores_codex":[0.9942966,0.001051303,0.002683686,0.0004798556,0.0009777887,0.000510791],"domain_scores_gemma":[0.9931069,0.002810341,0.001883421,0.001447695,0.0003396881,0.0004119246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.988233,0.005994809,0.0006302841,0.001199522,0.001179966,0.00002520329,0.001059357,0.0001082697,0.0004081691,0.00005477485,0.000536601,0.0005700499],"study_design_scores_gemma":[0.9819223,0.0007516201,0.0006789443,0.01151915,0.001358104,0.00002114521,0.0003077734,0.001844709,0.001186973,0.0001281117,0.000006300471,0.000274843],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773655,0.005507564,0.000003557457,0.000501397,0.0004439998,0.01547787,0.0002868025,0.00007695512,0.0003363736],"genre_scores_gemma":[0.9974743,0.0009838016,0.00002533882,0.0002046621,0.00003795413,0.0006876458,0.00007666033,0.00006623571,0.0004433821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02010884,"threshold_uncertainty_score":0.9999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06634695926808125,"score_gpt":0.3262672122342755,"score_spread":0.2599202529661942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}