{"id":"W2950101483","doi":"10.1002/mdc3.12803","title":"Second‐Generation Antisense Nucleotide Targeting Huntingtin Expression Found to Be Safe in Patients With Huntington's Disease","year":2019,"lang":"en","type":"article","venue":"Movement Disorders Clinical Practice","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Huntingtin; Medicine; Huntington's disease; Huntingtin Protein; Trinucleotide repeat expansion; Internal medicine; Clinical endpoint; Disease; Polyglutamine tract; Chorea; Pharmacology; Oncology; Clinical trial; Genetics; Biology; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004578191,0.0003923723,0.001556269,0.0002107478,0.0001988154,0.0002864564,0.0002954483,0.0006739897,0.001860856],"category_scores_gemma":[0.0005155032,0.000276667,0.000507289,0.000194956,0.0005202891,0.0003172894,0.0001471784,0.001072839,0.0002226718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103187,"about_ca_system_score_gemma":0.0004839561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005205034,"about_ca_topic_score_gemma":0.001223837,"domain_scores_codex":[0.9998307,0.00006369805,0.0000161558,0.00003554773,0.00002315927,0.00003069594],"domain_scores_gemma":[0.9997364,0.00006940831,0.00005402747,0.00003052374,0.00001621254,0.00009345371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6873096,0.02136537,0.003588595,0.0006656841,0.0007019153,0.0004817676,0.0003273702,0.0008950055,0.1590537,0.0003813655,0.001207584,0.124022],"study_design_scores_gemma":[0.2576624,0.7037988,0.01604599,0.0000503757,0.0005015149,0.0004163704,0.00007291458,0.00110452,0.01700909,0.0001989848,0.00309038,0.00004849409],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968676,0.001859335,0.0003136258,0.0001246847,0.0000908609,0.0002212027,0.0001006533,0.00002436437,0.0003975816],"genre_scores_gemma":[0.9973068,0.0009890725,0.000584307,0.0001662911,0.00006523565,0.0002473674,0.0001072959,0.000004008438,0.0005296589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860856,"threshold_uncertainty_score":0.006225169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933209818550206,"score_gpt":0.3180164790751053,"score_spread":0.2886843808896032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}