{"id":"W2950118514","doi":"10.1021/ol047498k","title":"Total Synthesis of (±)-Herbindole B and (±)-<i>cis</i>-Trikentrin B","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Stereochemistry; Total synthesis; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127996,0.0003777611,0.0003121976,0.0002766417,0.0002147978,0.0001905197,0.0003026876,0.0002490779,0.00349606],"category_scores_gemma":[0.0001121533,0.0002111545,0.0001931513,0.000271279,0.0001464158,0.0002393968,0.0003076777,0.0003453148,0.001282376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805902,"about_ca_system_score_gemma":0.0004082511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004017056,"about_ca_topic_score_gemma":0.0007170899,"domain_scores_codex":[0.9999125,0.000008992742,0.000007594634,0.00002241838,0.00002118104,0.00002726745],"domain_scores_gemma":[0.9999341,0.000005498566,0.00001405316,0.000009471911,0.00001274925,0.00002417116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001268471,0.00003976322,0.00005809588,0.0001899275,0.00001793192,0.0001869772,0.00003815359,0.0004203157,0.98632,0.0008497927,0.0002809144,0.01147124],"study_design_scores_gemma":[0.00003938897,0.0004158982,0.0004883902,0.00001334723,0.00002163593,0.0003264298,0.00001800767,0.0004574206,0.9866586,0.0001747623,0.01137066,0.00001550967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8974579,0.005197298,0.05744195,0.0001790995,0.0002691453,0.0005279314,0.002344405,0.001048568,0.03553369],"genre_scores_gemma":[0.951618,0.003291512,0.02923962,0.0001128194,0.00002101777,0.0002509913,0.001251459,0.000125964,0.0140887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00349606,"threshold_uncertainty_score":0.01169544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004304452394612714,"score_gpt":0.1987529643097816,"score_spread":0.1944485119151689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}