{"id":"W2950158180","doi":"10.1097/01.hs9.0000563624.30413.c3","title":"PS1336 DISCREPANCE OF ALLELIC BURDEN CHANGES AND CLINICAL RESPONSE IN PATIENTS WITH HIGHER RISK MYELODYSPLASTIC SYNDROME TREATED WITH HYPOMETHYLATING AGENTS","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Decitabine; Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; International Prognostic Scoring System; Hypomethylating agent; Allele; Gastroenterology; Myeloid; Oncology; Bone marrow; Gene; Genetics; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247753,0.0001297456,0.0002123572,0.0003839096,0.0001694586,0.0002428894,0.0001118046,0.0001676997,0.0008543444],"category_scores_gemma":[0.0007745,0.00007729832,0.0001249486,0.0002980451,0.0001570246,0.0001466231,0.0001672526,0.0002001247,0.0001270275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105407,"about_ca_system_score_gemma":0.000109981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005201009,"about_ca_topic_score_gemma":0.0005016857,"domain_scores_codex":[0.9998522,0.00003575805,0.00001876091,0.00004038658,0.00003197185,0.0000209921],"domain_scores_gemma":[0.9996239,0.00008927516,0.0001716783,0.00002355694,0.00003771431,0.00005386403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001139535,0.00004277619,0.9796221,0.00001301584,0.00004466009,0.0005101463,0.0001236687,0.0002340713,0.009046613,0.00002348538,0.0001024704,0.00909749],"study_design_scores_gemma":[0.00002540296,0.0004416025,0.995125,0.000002961635,0.00003886142,0.001755408,0.00006373659,0.0004016212,0.001764335,0.00004805368,0.0003296285,0.000003342882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996855,0.00008776608,0.00004046632,0.000008938899,9.392965e-7,0.000001934377,0.00004136641,0.000002197923,0.0001308594],"genre_scores_gemma":[0.9997749,0.00002263741,0.00004645661,0.000006894143,0.000002077726,0.000002055444,0.00008869253,8.464343e-7,0.00005555421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008543444,"threshold_uncertainty_score":0.002858043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555620643392143,"score_gpt":0.2852610328947903,"score_spread":0.2697048264608689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}