{"id":"W2950158180","doi":"10.1097/01.hs9.0000563624.30413.c3","title":"PS1336 DISCREPANCE OF ALLELIC BURDEN CHANGES AND CLINICAL RESPONSE IN PATIENTS WITH HIGHER RISK MYELODYSPLASTIC SYNDROME TREATED WITH HYPOMETHYLATING AGENTS","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Decitabine; Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; International Prognostic Scoring System; Hypomethylating agent; Allele; Gastroenterology; Myeloid; Oncology; Bone marrow; Gene; Genetics; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005643492,0.0002433295,0.0006781132,0.0001247135,0.0000361444,0.00001251762,0.0001168137,0.0001631461,0.0003946525],"category_scores_gemma":[0.0003059758,0.0001598325,0.00003928655,0.000496756,0.0001882415,0.00008784304,0.0001006194,0.0004840384,0.0000428202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001444783,"about_ca_system_score_gemma":0.0001463486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00035067,"about_ca_topic_score_gemma":0.00009311031,"domain_scores_codex":[0.9978129,0.000317625,0.0003946203,0.0005178599,0.0005492059,0.0004077775],"domain_scores_gemma":[0.9982202,0.0006883219,0.0002391829,0.0004960049,0.0001512997,0.0002049751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01566654,0.0001914472,0.9807756,0.0001891131,0.0002138797,0.0001801136,0.0001984425,0.00002747517,0.0001880966,0.000003815854,0.0000515237,0.002313971],"study_design_scores_gemma":[0.0112976,0.006441697,0.9801487,0.0007735773,0.0001124726,0.0000270089,0.000186198,0.0005060429,0.00008302382,0.000003621683,0.0002322381,0.0001877747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980566,0.0001512186,0.000007530792,0.0002578491,0.00002623926,0.000992539,0.00002232702,0.00003539184,0.0004503],"genre_scores_gemma":[0.9950393,0.00006961652,0.001446604,0.00004326455,0.00003048688,0.00002517384,0.00002363847,0.00006015192,0.003261718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00625025,"threshold_uncertainty_score":0.651778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555620643392143,"score_gpt":0.2852610328947903,"score_spread":0.2697048264608689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}